Human Melanocortin 5 Receptor (MC5R) Protein
208€ (10 µg)
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name
Human Melanocortin 5 Receptor (MC5R) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx654333
tested applications
WB, SDS-PAGE
Description
Human Melanocortin 5 Receptor (MC5R) Protein is a Recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Melanocortin 5 Receptor (MC5R) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 11.5 kDa Observed MW: 12 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Gly37+Leu98-Ile114+Tyr180-Val186+Gln266-Phe273 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | MC5R,MC2,melanocortin receptor 5 |
| Background | Protein MC5R |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
MC5R is a G protein-coupled receptor activated by melanocortins, including α-MSH and ACTH. It is widely expressed in various peripheral tissues, including the skin, adrenal glands, and exocrine glands. MC5R regulates the production of sebaceous lipids in sebaceous glands, contributing to skin and hair lubrication and barrier function. It also influences inflammatory responses, immune regulation, and steroidogenesis. In immune cells, MC5R activation suppresses pro-inflammatory cytokine production, highlighting its role in anti-inflammatory processes. Dysregulation of MC5R has been implicated in skin disorders such as acne, where altered lipid production disrupts skin homeostasis. MC5R may also play a role in regulating energy metabolism, muscle growth, and thermogenesis. Therapeutically, MC5R agonists are being explored for their potential in treating inflammatory skin conditions, metabolic dysfunction, and immune-related disorders. Its diverse roles in lipid production, inflammation, and tissue homeostasis make MC5R a promising target for skin and metabolic therapies.
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