Human Matrix Metalloproteinase 3 / Stromelysin-1 (MMP3) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human MMP3 concentrations in serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. This assay has high sensitivity and excellent specificity for detection of MMP3No significant cross-reactivity or interference between MMP3 and analogues was observed.
MMPs are secreted by diverse connective tissue and pro-inflammatory cells. Typically, these enzymes exhibit minimal expression under normal physiological circumstances. MMPs assume a pivotal role in various cellular processes, including cell proliferation, migration, differentiation, angiogenesis, apoptosis, and immunity. They share a common domain structure, consisting of three key components. First is the pro-peptide, which requires removal to activate the enzyme. Next, there is the catalytic domain, featuring a cysteine switch, where a cysteine residue interacts with zinc, and the haemopexin-like C-terminal domain is linked to the catalytic domain via a flexible hinge region. Stromelysin-1, also recognized as matrix metalloproteinase-3 (MMP-3), is an enzyme encoded by the MMP3 gene in humans. Aliases are: CHDS6, MMP-3, SL-1, STMY, STMY1, and STR1.This enzyme plays a significant role in the degradation of fibronectin, laminin, as well as collagens III, IV, IX, and X, along with cartilage proteoglycans. MMP-3 is involved in various biological processes such as wound repair, the progression of atherosclerosis, and the initiation of tumors.
MMPs son secretadas por diversos tejidos conectivos y células proinflamatorias. Normalmente, estas enzimas exhiben una expresión mínima en circunstancias fisiológicas normales. Las MMP asumen un papel fundamental en diversos procesos celulares, incluida la proliferación, migración, diferenciación, angiogénesis, apoptosis e inmunidad celular. Comparten una estructura de dominio común, que consta de tres componentes clave. El primero es el propéptido, que requiere eliminación para activar la enzima. A continuación, está el dominio catalítico, que presenta un interruptor de cisteína, donde un residuo de cisteína interactúa con el zinc, y el dominio C-terminal similar a hemopexina está unido al dominio catalítico a través de una región bisagra flexible. La estromelisina-1, también reconocida como metaloproteinasa de matriz-3 (MMP-3), es una enzima codificada por el gen MMP3 en humanos. Los alias son: CHDS6, MMP-3, SL-1, STMY, STMY1 y STR1. Esta enzima juega un papel importante en la degradación de la fibronectina, la laminina, así como los colágenos III, IV, IX y X, junto con el cartílago. proteoglicanos. MMP-3 participa en diversos procesos biológicos, como la reparación de heridas, la progresión de la aterosclerosis y la iniciación de tumores.
ELISA Kits
Matrix Metalloproteinase 3 / Stromelysin-1 (MMP3)
Human
31.2 pg/ml - 2000 pg/ml
< 12.5 pg/ml
Sandwich
Quantitative
Colorimetric
Serum,Plasma,Tissue homogenates,Cell lysates,Other biological fluids
96 tests
5 × 96 tests
10 × 96 tests
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
MMP3
No
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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