Human Mannose Receptor C Type 2 (MRC2) Protein

Este producto es parte de MRC2 - mannose receptor C-type 2
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234€ (10 µg)

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935106861
info@markelab.com
name
Human Mannose Receptor C Type 2 (MRC2) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx167121
tested applications
WB, SDS-PAGE

Description

Mannose Receptor C Type 2 Protein is a recombinant Human protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Mannose Receptor C Type 2 (MRC2)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 56.6 kDa  Observed MW (SDS-PAGE): 57 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Pro41-Lys505
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Alias
C-type mannose receptor 2,CD280,UPARAP,CLEC13E,ENDO180,C-type lectin domain family 13 member E,Endocytic receptor 180,UPAR-associated protein
Background
Protein MRC2
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Mannose receptor C-type 2 (MRC2), also known as endocytic mannose receptor or uPARAP/Endo180, is a transmembrane glycoprotein receptor and a member of the C-type lectin family. MRC2 plays a significant role in the cellular processes of endocytosis and extracellular matrix (ECM) remodeling, particularly through binding and internalizing glycoproteins and matrix components. MRC2 is predominantly expressed in cells with endocytic functions, including fibroblasts, macrophages, and endothelial cells, and contributes to tissue homeostasis, immune response, and wound healing by modulating cellular uptake of glycosylated and collagenous materials. MRC2 is one of several mannose receptors, structurally distinct from others such as MRC1. Unlike MRC1, which is primarily involved in antigen capture and immune surveillance, MRC2 is most notable for its role in collagen uptake and degradation, positioning it as a unique player in matrix remodeling and turnover. The receptor's collagen-binding capacity has been linked to its role in tumor progression and metastasis in cancer as well as in fibrosis, where excessive ECM accumulation disrupts normal tissue function.

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