Human Macrophage Colony Stimulating Factor Receptor (CSF1R) ELISA Kit
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Description
Human Macrophage Colony Stimulating Factor Receptor (CSF1R) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human MCSFR concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Macrophage Colony Stimulating Factor Receptor (CSF1R) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 62.5 pg/ml - 4000 pg/ml |
| Sensitivity | 37.5 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P07333 |
| Alias | Macrophage colony-stimulating factor 1 receptor,FMS,CSFR,FIM2,GPSC,HDLS,C-FMS,CD115,HDLS1,CSF-1R,BANDDOS,M-CSF-R,Proto-oncogene c-Fms,CSF-1 receptor |
| Background | Elisa kits for CSF1R |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
The Colony Stimulating Factor 1 Receptor (CSF1R), also known as macrophage colony-stimulating factor receptor or CD115, is a cell surface receptor that primarily regulates the survival, proliferation, and differentiation of monocytes, macrophages, and osteoclasts. CSF1R is a transmembrane protein belonging to the receptor tyrosine kinase (RTK) family and is activated by binding to its primary ligand, colony-stimulating factor 1 (CSF1), as well as the alternative ligand interleukin-34 (IL-34). This receptor is essential for various immune functions and bone metabolism, primarily because of its role in maintaining and activating macrophage populations. The CSF1R gene is located on chromosome 5 (5q32) and encodes a protein that is essential in regulating macrophage differentiation, survival, and function. CSF1R signaling influences immune response, inflammation, tissue homeostasis, and bone remodeling. Dysregulation of CSF1R or its signaling pathways has been associated with pathological conditions such as inflammatory diseases, cancer, and neurodegenerative disorders. Furthermore, mutations in CSF1R have been implicated in a group of disorders characterized by leukoencephalopathy and early-onset neurodegeneration.
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