Human Lysosomal Associated Membrane Protein 2 (LAMP2) Protein
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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein LAMP2
proveedor
Abbexareference
abx067862Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Recombinant Lysosomal Associated Membrane Protein 2 (LAMP2) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
Lysosome-associated membrane glycoprotein 2 (LAMP2) is a critical lysosomal membrane protein involved in autophagy, lysosomal biogenesis, and cellular homeostasis LAMP2 facilitates the fusion of autophagosomes with lysosomes, enabling the degradation of cellular components during autophagy LAMP2 exists in three isoforms (LAMP2A, LAMP2B, and LAMP2C), each with distinct roles in lysosome function LAMP2A is essential for chaperone-mediated autophagy (CMA), where it mediates the selective degradation of cytosolic proteins LAMP2B is primarily involved in macroautophagy, particularly in muscle and neuronal tissues Mutations in LAMP2 cause Danon disease, a rare lysosomal storage disorder characterized by cardiomyopathy, myopathy, and intellectual disability LAMP2 dysregulation has been linked to neurodegenerative diseases and cancers, where impaired autophagy disrupts cellular homeostasis and promotes disease progression LAMP2 also plays a role in immune responses, contributing to antigen processing and lysosomal exocytosis Its importance in autophagy, cellular stress responses, and disease underscores its critical role in maintaining cellular integrity
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Lysosomal Associated Membrane Protein 2 (LAMP2)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 49.9 kDa Observed MW (SDS-PAGE): 50 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys193-Asn375 Tag: N-terminal His tag and GST tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
LAMP2
dry ice
No
availability
Shipped within 5-7 working days.
alias
CD107b,DND,LAMP-2,LAMPB,LGP-96,LGP110
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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