Human Lysosomal Associated Membrane Protein 1 (LAMP1) Protein

Este producto es parte de LAMP- Lysosomal Associated Membrane Protein
Human Lysosomal Associated Membrane Protein 1 (LAMP1) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein LAMP1

proveedor

Abbexa

reference

abx067859

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Lysosomal Associated Membrane Protein 1 (LAMP1) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

Lysosome-associated membrane glycoprotein 1 (LAMP1) is a transmembrane protein located on the lysosomal membrane that plays a key role in lysosome integrity, autophagy, and cellular homeostasis LAMP1 is highly expressed in cells undergoing autophagy, where it contributes to lysosomal stability and fusion with autophagosomes for the degradation of cellular waste It is involved in lysosome exocytosis, which regulates plasma membrane repair, pathogen clearance, and cellular stress responses LAMP1 also serves as a marker for lysosomal activity and has been implicated in immune responses, particularly in natural killer (NK) cell-mediated cytotoxicity Dysregulation of LAMP1 expression has been observed in neurodegenerative diseases such as Parkinson’s and Alzheimer’s, where impaired lysosomal function leads to protein aggregation and cellular toxicity Additionally, LAMP1 overexpression is associated with cancer progression and metastasis, where it facilitates cellular invasion through lysosome-mediated extracellular matrix degradation Its role in maintaining lysosomal function underscores its importance in cellular health and disease pathology

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Lysosomal Associated Membrane Protein 1 (LAMP1)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 56.9 kDa Observed MW (SDS-PAGE): 57 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Ala49-Ser297 Tag: N-terminal His tag and GST tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

LAMP1


dry ice

No


availability

Shipped within 5-7 working days.


alias

LAMPA,CD107a,LGP120,CD107 antigen-like family member A


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


Quizá le pueda interesar

Human LAMP1(lysosomal-associated membrane protein 1) ELISA Kit

Human LAMP1(lysosomal-associated membrane protein 1) ELISA Kit

proveedor

FineTest

reference

EH9718

reactivity

human

status

RUO

Precio a consultar

Ver más

Mouse LAMP1(Lysosomal Associated Membrane Protein 1) ELISA Kit

Mouse LAMP1(Lysosomal Associated Membrane Protein 1) ELISA Kit

proveedor

FineTest

reference

EM1182

reactivity

mouse

status

RUO

Precio a consultar

Ver más

anti- LAMP1 antibody

anti- LAMP1 antibody

proveedor

FineTest

reference

FNab04684

Tested Applications

ELISA, WB, IHC, IF

reactivity

human,mouse,rat

status

RUO

clonality

polyclonal

The protein encoded by this gene is a member of a family of membrane glycoproteins. This glycoprotein provides selectins...

Precio a consultar

Ver más