Human Lymphocyte Function Associated Antigen 3 / LFA-3 (CD58) Protein
234€ (5 µg)
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name
Human Lymphocyte Function Associated Antigen 3 / LFA-3 (CD58) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx680402
tested applications
SDS-PAGE
Description
Human Lymphocyte Function Associated Antigen 3 / LFA-3 (CD58) Protein is a recombinant protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Lymphocyte Function Associated Antigen 3 / LFA-3 (CD58) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 5 µg |
| Size 2 | 20 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| Alias | ag3,LFA3,LFA-3,Lymphocyte function-associated antigen 3,Surface glycoprotein LFA-3 |
| Background | Protein CD58 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CD58, also known as Lymphocyte Function-associated Antigen 3 (LFA-3), is a cell surface glycoprotein primarily involved in cell adhesion processes. It plays a critical role in the immune response by mediating the interaction between T cells and antigen-presenting cells (APCs). The CD58 protein is a member of the immunoglobulin (Ig) superfamily and is widely expressed on a variety of cell types, including epithelial cells, endothelial cells, lymphocytes, and dendritic cells. Its main binding partner is CD2, a receptor found on T cells and natural killer (NK) cells. This interaction is essential for the formation of the immune synapse, facilitating the activation of T cells and subsequent immune responses. CD58’s role is especially important in antigen presentation, where it helps T cells to recognize and respond to foreign antigens. The molecule is involved in co-stimulation during T-cell receptor (TCR) engagement, enhancing the immune system's ability to respond to pathogens, tumors, and other immunological challenges.
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Ligand of the T-lymphocyte CD2 glycoprotein. This interaction is important in mediating thymocyte interactions with thymic epithelial cells, antigen-independent and-dependent interactions of T-lymphocytes with target cells and antigen-presenting cells and the T-lymphocyte rosetting with erythrocytes. In addition, the LFA-3/CD2 interaction may prime response by both the CD2+ and LFA-3+ cells.
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