Human Lutropin-Choriogonadotropic Hormone Receptor (LHCGR) ELISA Kit
559€ (96 tests)
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935106861
info@markelab.com
name
Human Lutropin-Choriogonadotropic Hormone Receptor (LHCGR) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx250883
tested applications
ELISA
Description
Human Lutropin-Choriogonadotropic Hormone Receptor (LHCGR) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Lutropin-choriogonadotropic hormone receptor concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Lutropin-Choriogonadotropic Hormone Receptor (LHCGR) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.087 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P22888 |
| Alias | LHCGR,Choriogonadotropin receptor,LCGR,LGR2,LHR, lutropin-choriogonadotropic hormone receptor,LH-R,Luteinizing Hormone/Choriogonadotropin Receptor, HHG,LH/CG-R,LH/CGR,LHR,LHRHR,LSH-R,ULG5 |
| Background | Elisa kits for LHCGR |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
LHCGR is a G protein-coupled receptor activated by luteinizing hormone (LH) and human chorionic gonadotropin (hCG), playing a crucial role in reproductive function. It is expressed in ovarian theca and granulosa cells in females and Leydig cells in males. In females, LHCGR regulates ovulation, corpus luteum formation, and progesterone production during the menstrual cycle and pregnancy. In males, LHCGR stimulates testosterone synthesis in Leydig cells, which supports spermatogenesis. LHCGR signaling activates adenylyl cyclase through Gs proteins, increasing cAMP levels and activating protein kinase A (PKA), which regulates steroidogenesis and cell proliferation. Mutations in LHCGR are linked to disorders such as precocious puberty, infertility, and hypogonadism. Overexpression of LHCGR has been observed in hormone-dependent cancers, including ovarian and testicular tumors, where it drives abnormal growth and survival. Therapeutically, LH/hCG analogs are used to treat infertility, while LHCGR antagonists are being explored for hormone-related cancers. LHCGR is vital for maintaining reproductive health and steroid hormone production.
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