Human Low Density Lipoprotein Receptor Related Protein 2 (LRP2) Protein

Este producto es parte de LRP2 - LDL receptor related protein 2
Human Low Density Lipoprotein Receptor Related Protein 2 (LRP2) Protein

Pida mas información

935106861

info@markelab.com

Precio

182€ (10 µg)

Protein LRP2

proveedor

Abbexa

reference

abx650292

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human LRP2 Protein is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

Low-Density Lipoprotein Receptor-Related Protein 2 (LRP2), also known as megalin, is a large endocytic receptor primarily known for its role in cellular uptake of a wide variety of ligands. LRP2 belongs to the LDL receptor family and is highly expressed in epithelial cells, particularly in the proximal tubule cells of the kidneys, the choroid plexus of the brain, and the inner ear. By binding and internalizing various ligands, including lipoproteins, vitamins, hormones, and protein complexes, LRP2 is essential for nutrient reabsorption, hormonal balance, and cellular signaling. LRP2’s functions are particularly significant in the kidneys, where it reabsorbs essential proteins and other molecules from the filtrate to prevent loss through urine. In the brain, it has roles in neurodevelopment and modulates responses to growth factors. LRP2’s complex functionality extends to embryonic development, where it influences morphogen signaling pathways critical to organ formation. Given its roles in various physiological systems, LRP2’s dysfunction or deficiency has been linked to developmental disorders, kidney disease, and metabolic syndromes.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Low Density Lipoprotein Receptor Related Protein 2 (LRP2)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 21.1 kDa Observed MW (SDS-PAGE): 25 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gly4035-Leu4184 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

LRP2


dry ice

No


availability

Shipped within 5-7 working days.


alias

Low-density lipoprotein receptor-related protein 2,DBS,GP330,LRP-2,Megalin


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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