Human Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) ELISA Kit
715€ (96 tests)
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name
Human Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx385102
tested applications
ELISA
Description
Human Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human LDLRAP1 concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Low Density Lipoprotein Receptor Adaptor Protein 1 (LDLRAP1) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.094 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q5SW96 |
| Gene ID | 26119 |
| OMIM | 603813 |
| Alias | LDLRAP1, ARH, ARH1, ARH2, FHCB1, FHCB2, low density lipoprotein receptor adaptor protein 1, FHCL4 |
| Background | Elisa kits for LDLRAP1 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Low-Density Lipoprotein Receptor Adapter Protein 1 (LDLRAP1), also known as ARH (autosomal recessive hypercholesterolemia protein), is a crucial adaptor protein that plays a pivotal role in the trafficking and internalization of low-density lipoprotein (LDL) receptors. It is predominantly expressed in hepatocytes and other tissues involved in cholesterol homeostasis. LDLRAP1 functions by linking the cytoplasmic tail of LDL receptors to clathrin-coated pits, facilitating receptor-mediated endocytosis of LDL particles. Mutations in the LDLRAP1 gene are associated with autosomal recessive hypercholesterolemia (ARH), a rare genetic disorder characterized by elevated plasma LDL cholesterol levels due to impaired clearance of LDL from circulation. This protein's interaction with other cellular components, such as AP-2 and clathrin, highlights its essential role in lipid metabolism and receptor recycling. As a significant contributor to cholesterol regulation, LDLRAP1 has been a subject of intense research, particularly for developing therapeutic strategies targeting cholesterol-related disorders.
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