Human Linker For Activation Of T-Cell (LAT) Protein

Este producto es parte de LAT - linker for activation of T cells
Human Linker For Activation Of T-Cell (LAT) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein LAT

proveedor

Abbexa

reference

abx166552

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Linker For Activation Of T-Cell Protein is a recombinant Human protein expressed in E. coli.


Background

The linker for activation of T cells (LAT) is a critical adaptor protein primarily expressed in T cells and natural killer (NK) cells. LAT serves as a central hub in T-cell receptor (TCR) signaling, playing a pivotal role in transmitting signals from the activated TCR complex to downstream pathways essential for T-cell activation, proliferation, and differentiation. Following TCR engagement, LAT becomes phosphorylated on its tyrosine residues, creating docking sites for multiple signaling molecules, including PLCγ1, Grb2, and Gads. This process orchestrates a cascade of events that culminates in calcium flux, MAPK activation, and cytoskeletal reorganization. LAT's proper functioning is indispensable for effective immune responses, and its dysregulation is linked to immune deficiencies and T-cell malignancies. Research into LAT has provided significant insights into T-cell signaling mechanisms and potential therapeutic targets for autoimmune diseases and cancers.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Linker For Activation Of T-Cell (LAT)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 24.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu25-Glu221 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

LAT


dry ice

No


availability

Shipped within 5-7 working days.


alias

LAT,36 kDa phospho-tyrosine adapter protein, LAT1,p36-38, pp36


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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