Human Leucine-Rich Repeat-Containing Protein 3B (LRRC3B) Protein

Este producto es parte de LRRC - Leucine-rich repeat-containing protein
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273€ (10 µg)

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935106861
info@markelab.com
name
Human Leucine-Rich Repeat-Containing Protein 3B (LRRC3B) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx690652
tested applications
SDS-PAGE

Description

Human Leucine-Rich Repeat-Containing Protein is a recombinant protein from Human produced in Human Cells. Recombinant Human Leucine-Rich Repeat-Containing Protein 3B is produced by our Mammalian expression system and the target gene encoding Cys34-Tyr204 is expressed with a 6His tag at the C-terminus.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Leucine-Rich Repeat-Containing
Host
Human
Origin
Human
Observed MW
Molecular Weight: 20 kDa
Sequence Fragment: Cys34-Tyr204
Tag: C-terminal 6 His tag
Expression
Recombinant
Purity
> 95% (SDS-PAGE)
Size 1
10 µg
Size 2
50 µg
Form
Lyophilized
Tested Applications
SDS-PAGE
Buffer
20mM Tris, 150mM NaCl, pH8.0.
Availability
Shipped within 5-15 working days.
Storage
Store at < -20°C.
Dry Ice
No
UniProt ID
Q96PB8
Alias
LRRC3B, LRP15,Leucine-rich repeat protein 15
Background
Protein LRRC3B
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

LRRC3B is a tumor suppressor protein expressed in various tissues where it modulates cell growth and apoptosis its expression is frequently downregulated in cancers such as gastric colorectal and breast cancer due to epigenetic silencing through promoter hypermethylation LRRC3B is believed to inhibit cancer progression by modulating Wnt/β-catenin signaling and other pathways involved in cell proliferation and survival loss of LRRC3B function contributes to tumorigenesis by disrupting cell cycle regulation and enhancing cellular migration and invasion studies indicate it may also influence the tumor microenvironment by regulating extracellular matrix remodeling and cell-cell adhesion its potential as a biomarker for early cancer detection and prognosis is being actively explored as is its reactivation through epigenetic therapies targeting promoter methylation further research is necessary to fully characterize its tumor-suppressive mechanisms and therapeutic applications in oncology
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