Human Leucine-rich repeat-containing protein 14 (LRRC14) ELISA Kit
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Description
Human Leucine-rich repeat-containing protein 14 (LRRC14) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Leucine-rich repeat-containing protein 14 (LRRC14) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Leucine-rich repeat-containing protein 14 (LRRC14) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q15048 |
| Gene ID | 9684 |
| Alias | KIAA0014 |
| Background | Elisa kits for LRRC14 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
LRRC14 is recognized as a regulator of transforming growth factor-beta (TGF-β) signaling and is predominantly expressed in immune and stromal cells where it modulates various biological responses linked to inflammation and fibrosis it functions as a TGF-β receptor-interacting protein acting as a negative regulator of TGF-β by preventing receptor activation and downstream Smad signaling pathways its expression is closely associated with cellular differentiation processes including the regulation of mesenchymal cell activity in wound healing and fibrotic tissue remodeling studies suggest that LRRC14 can influence tumor microenvironments by altering TGF-β activity contributing to either suppression or promotion of tumor growth depending on the context its dysregulation has been implicated in conditions such as cancer-related fibrosis and autoimmune diseases making it a target of interest for therapeutic modulation additional research is being conducted to better understand its interactions with other cytokine networks and its potential as a biomarker for fibrotic and oncologic disorders
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