Human L1-Cell Adhesion Molecule (L1CAM) Protein

Background

L1 Cell Adhesion Molecule (L1CAM) is a critical protein in the nervous system that belongs to the immunoglobulin superfamily. It plays a significant role in neural development, influencing processes such as axonal guidance, neuronal migration, and synaptic plasticity. L1CAM is predominantly expressed in the brain but is also found in other tissues, contributing to various cellular interactions. It is a transmembrane glycoprotein that mediates homophilic (L1-L1) and heterophilic (L1 with other molecules) binding, facilitating cell-cell adhesion and communication. Research into L1CAM has provided insights into its importance in both normal neural development and pathological conditions.