Human KPNA4 (Karyopherin subunit alpha-4) ELISA Kit
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Name
Human KPNA4 (Karyopherin subunit alpha-4) ELISA Kit
Category
ELISA Kits
Provider
FineTest
Reference
EH9680
Tested Applications
ELISA
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | 4 hours |
| Assay Type | Sandwich ELISA, Double Antibody |
| Test Range | 31.25-2000pg/ml |
| Sensitivity | 18.75ng/ml |
| Size 1 | 96T |
| Tested Applications | ELISA |
| Sample Type | Serum, Plasma, Cell Culture Supernatant, cell or tissue lysate, Other liquid samples |
| Availability | Shipped within 10-14 working days. |
| Storage | 2-8 °C for 12 months |
| UniProt ID | O00629 |
| Alias | KPNA4,IPOA3, QIP1, SRP3, Importin subunit alpha-3 |
| Background | Elisa kits for KPNA4 |
| Status | RUO |
Background
KPNA4, also known as importin-α3, is a nuclear transport adaptor protein that recognizes classical nuclear localization signals (NLS) in cargo proteins and facilitates their nuclear import via the importin-β pathway. KPNA4 binds cargo proteins, such as transcription factors and kinases, forming a complex that translocates through the nuclear pore complex (NPC). It is widely expressed and plays critical roles in cell cycle regulation, transcriptional control, and stress responses. KPNA4 is implicated in viral replication by mediating the nuclear import of viral proteins in pathogens like HIV and influenza virus. Dysregulation of KPNA4 has been linked to cancers, where it enhances nuclear transport of oncogenic proteins and supports tumor progression. Knockdown studies show its role in maintaining proper cellular signaling, highlighting its importance in development, differentiation, and immune responses.
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