Human Killer Cell Immunoglobulin-Like Receptor 2DL4 (KIR2DL4) Protein
1079€ (100 µg)
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935106861
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name
Human Killer Cell Immunoglobulin-Like Receptor 2DL4 (KIR2DL4) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx693714
tested applications
SDS-PAGE
Description
Human KIR2DL4 Protein is a recombinant protein from Human produced in CHO Stable Cells. A DNA sequence encoding the human KIR2DL4 (ADY38409.1)(Met1-His242) was expressed with six amino acids (LEVLFQ) at the C-terminus was expressed and purified.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | KIR2DL4 |
| Host | CHO cells |
| Origin | Human |
| Observed MW | Molecular Weight: 25.1 kDa Sequence Fragment: Met1-His242 Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 85% (SDS-PAGE) |
| Size 1 | 100 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | ADY38409.1 |
| Alias | CD158 antigen-like family member D,G9P,CD158D,KIR103,KIR-2DL4,KIR103AS,KIR-103AS,Killer cell inhibitory receptor 103AS,MHC class I NK cell receptor KIR103AS |
| Background | Protein KIR2DL4 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
KIR2DL4 is a member of the killer cell immunoglobulin-like receptor (KIR) family, which plays an essential role in immune regulation, particularly through the modulation of natural killer (NK) cell activity. KIR2DL4 is unique among KIRs in its ability to transduce both activating and inhibitory signals, allowing it to play a nuanced role in immune responses. Unlike most KIRs, which are specific to either HLA-A, -B, or -C, KIR2DL4 binds specifically to HLA-G, a non-classical MHC class I molecule. HLA-G is primarily expressed in tissues with immune privilege, such as the placenta, where it contributes to immune tolerance, thus implicating KIR2DL4 in maternal-fetal immune interactions. The gene encoding KIR2DL4 is located on chromosome 19q13.4, within the leukocyte receptor complex (LRC), alongside other KIR genes. The KIR family is highly polymorphic, resulting in a wide array of receptor-ligand combinations that contribute to individual variations in immune responses. KIR2DL4’s interaction with HLA-G is particularly important for its role in promoting tolerance in pregnancy and its potential involvement in immune responses to certain infections and cancers.
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