Human Killer Cell Immunoglobulin-Like Receptor 2DL4 (KIR2DL4) Protein
247€ (10 µg)
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935106861
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name
Human Killer Cell Immunoglobulin-Like Receptor 2DL4 (KIR2DL4) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx690660
tested applications
SDS-PAGE
Description
Human KIR2DL4 Protein is a recombinant protein from Human produced in Human Cells. Recombinant Human Killer cell immunoglobulin-like receptor 2DL4 is produced by our Mammalian expression system and the target gene encoding Trp22-His242 is expressed with a 6His tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | KIR2DL4 |
| Host | Human |
| Origin | Human |
| Observed MW | Molecular Weight: 25.3 kDa Sequence Fragment: Trp22-His242 Tag: C-terminal 6 His tag |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | 20mM PB, 150mM NaCl, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store at < -20°C. |
| Dry Ice | No |
| UniProt ID | Q99706 |
| Alias | CD158 antigen-like family member D,G9P,CD158D,KIR103,KIR-2DL4,KIR103AS,KIR-103AS,Killer cell inhibitory receptor 103AS,MHC class I NK cell receptor KIR103AS |
| Background | Protein KIR2DL4 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
KIR2DL4 is a member of the killer cell immunoglobulin-like receptor (KIR) family, which plays an essential role in immune regulation, particularly through the modulation of natural killer (NK) cell activity. KIR2DL4 is unique among KIRs in its ability to transduce both activating and inhibitory signals, allowing it to play a nuanced role in immune responses. Unlike most KIRs, which are specific to either HLA-A, -B, or -C, KIR2DL4 binds specifically to HLA-G, a non-classical MHC class I molecule. HLA-G is primarily expressed in tissues with immune privilege, such as the placenta, where it contributes to immune tolerance, thus implicating KIR2DL4 in maternal-fetal immune interactions. The gene encoding KIR2DL4 is located on chromosome 19q13.4, within the leukocyte receptor complex (LRC), alongside other KIR genes. The KIR family is highly polymorphic, resulting in a wide array of receptor-ligand combinations that contribute to individual variations in immune responses. KIR2DL4’s interaction with HLA-G is particularly important for its role in promoting tolerance in pregnancy and its potential involvement in immune responses to certain infections and cancers.
