Human Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4) ELISA Kit
715€ (96 tests)
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935106861
info@markelab.com
name
Human Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx529938
tested applications
ELISA
Description
Human Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.06 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q99706 |
| Alias | CD158 antigen-like family member D,G9P,CD158D,KIR103,KIR-2DL4,KIR103AS,KIR-103AS,Killer cell inhibitory receptor 103AS,MHC class I NK cell receptor KIR103AS |
| Background | Elisa kits for KIR2DL4 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
KIR2DL4 is a member of the killer cell immunoglobulin-like receptor (KIR) family, which plays an essential role in immune regulation, particularly through the modulation of natural killer (NK) cell activity. KIR2DL4 is unique among KIRs in its ability to transduce both activating and inhibitory signals, allowing it to play a nuanced role in immune responses. Unlike most KIRs, which are specific to either HLA-A, -B, or -C, KIR2DL4 binds specifically to HLA-G, a non-classical MHC class I molecule. HLA-G is primarily expressed in tissues with immune privilege, such as the placenta, where it contributes to immune tolerance, thus implicating KIR2DL4 in maternal-fetal immune interactions. The gene encoding KIR2DL4 is located on chromosome 19q13.4, within the leukocyte receptor complex (LRC), alongside other KIR genes. The KIR family is highly polymorphic, resulting in a wide array of receptor-ligand combinations that contribute to individual variations in immune responses. KIR2DL4’s interaction with HLA-G is particularly important for its role in promoting tolerance in pregnancy and its potential involvement in immune responses to certain infections and cancers.
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