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Human Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4) ELISA Kit
Pida mas información
935106861
info@markelab.com
Precio
687.5€ (96 tests)
Elisa Kits KIR2DL4
proveedor
Abbexareference
abx529938Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4) concentrations in tissue homogenates, cell lysates and other biological fluids.
Background
KIR2DL4 is a member of the killer cell immunoglobulin-like receptor (KIR) family, which plays an essential role in immune regulation, particularly through the modulation of natural killer (NK) cell activity. KIR2DL4 is unique among KIRs in its ability to transduce both activating and inhibitory signals, allowing it to play a nuanced role in immune responses. Unlike most KIRs, which are specific to either HLA-A, -B, or -C, KIR2DL4 binds specifically to HLA-G, a non-classical MHC class I molecule. HLA-G is primarily expressed in tissues with immune privilege, such as the placenta, where it contributes to immune tolerance, thus implicating KIR2DL4 in maternal-fetal immune interactions. The gene encoding KIR2DL4 is located on chromosome 19q13.4, within the leukocyte receptor complex (LRC), alongside other KIR genes. The KIR family is highly polymorphic, resulting in a wide array of receptor-ligand combinations that contribute to individual variations in immune responses. KIR2DL4’s interaction with HLA-G is particularly important for its role in promoting tolerance in pregnancy and its potential involvement in immune responses to certain infections and cancers.
Características del producto
category
ELISA Kits
immunogen target
Killer cell immunoglobulin-like receptor 2DL4 (KIR2DL4)
reactivity
Human
test range
0.156 ng/ml - 10 ng/ml
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
alias
CD158 antigen-like family member D,G9P,CD158D,KIR103,KIR-2DL4,KIR103AS,KIR-103AS,Killer cell inhibitory receptor 103AS,MHC class I NK cell receptor KIR103AS
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
KIR2DL4
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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