Human Keratin 8 (KRT8) Protein

Este producto es parte de KRT8 - Keratin 8 (Cytokeratin 8)
Human Keratin 8 (KRT8) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein KRT8

proveedor

Abbexa

reference

abx067633

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Keratin 8 (KRT8) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

Keratin 8 (KRT8) is a type II intermediate filament protein primarily expressed in simple epithelial tissues, including the gastrointestinal tract, liver, and lungs, where it provides mechanical support and structural stability to epithelial cells KRT8 pairs with keratin 18 (KRT18) to form heterodimers that assemble into intermediate filaments, maintaining cytoskeletal integrity and cell resilience under mechanical and chemical stress KRT8 is involved in cell signaling, apoptosis, and protection against oxidative stress, contributing to epithelial cell survival Dysregulation or mutations in KRT8 are associated with liver diseases such as steatohepatitis, cirrhosis, and hepatocellular carcinoma, where KRT8 aggregates can impair cellular function KRT8 also participates in tumorigenesis by promoting epithelial-mesenchymal transition (EMT), enhancing cancer cell migration, invasion, and metastasis Elevated KRT8 expression is observed in various cancers, including colorectal, breast, and pancreatic cancer, where it serves as a diagnostic marker for disease progression and prognosis

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Keratin 8 (KRT8)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 41.9 kDa Observed MW (SDS-PAGE): 26 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Lys92-Lys393 Tag: N-terminal His tag


expression

Recombinant


purity

> 97%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

KRT8


dry ice

No


availability

Shipped within 5-7 working days.


alias

K8,KO,CK8,CK-8,CYK8,K2C8,CARD2,Cytokeratin-8,Keratin-8,Type-II keratin Kb8


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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