Human Keratin 8 (KRT8) CLIA Kit
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Description
Human Keratin 8 (KRT8) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Serum, plasma, tissue homogenates, cell lysates, cell culture supernates and other biological fluids.
Documents del producto
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Keratin 8 (KRT8) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.057 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | K8,KO,CK8,CK-8,CYK8,K2C8,CARD2,Cytokeratin-8,Keratin-8,Type-II keratin Kb8 |
| Background | CLIA Kits KRT8 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
Keratin 8 (KRT8) is a type II intermediate filament protein primarily expressed in simple epithelial tissues, including the gastrointestinal tract, liver, and lungs, where it provides mechanical support and structural stability to epithelial cells KRT8 pairs with keratin 18 (KRT18) to form heterodimers that assemble into intermediate filaments, maintaining cytoskeletal integrity and cell resilience under mechanical and chemical stress KRT8 is involved in cell signaling, apoptosis, and protection against oxidative stress, contributing to epithelial cell survival Dysregulation or mutations in KRT8 are associated with liver diseases such as steatohepatitis, cirrhosis, and hepatocellular carcinoma, where KRT8 aggregates can impair cellular function KRT8 also participates in tumorigenesis by promoting epithelial-mesenchymal transition (EMT), enhancing cancer cell migration, invasion, and metastasis Elevated KRT8 expression is observed in various cancers, including colorectal, breast, and pancreatic cancer, where it serves as a diagnostic marker for disease progression and prognosis
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This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene.
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Keratins are a large family of proteins that form the intermediate filament cytoskeleton of epithelial cells, which are classified into two major sequence types. Type I keratins are a group of acidic intermediate filament proteins, including K9–K23, and the hair keratins Ha1–Ha8. Type II keratins are the basic or neutral courterparts to the acidic type I keratins, including K1–K8, and the hair keratins, Hb1–Hb6. KRT8 is often paired with keratin 18 in vivo.
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