Human Interleukin 34 (IL34) Protein
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935106861
info@markelab.com
Precio
208€ (10 µg)
Protein IL34
proveedor
Abbexareference
abx654031Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Interleukin 34 (IL34) Protein is a Recombinant Human protein expressed in E. coli.
Background
Interleukin 34 (IL34) is a pro-inflammatory cytokine identified in 2008 through bioinformatics analysis of the human genome. Unlike most interleukins, which were discovered through their immunological properties, IL-34 was initially identified for its role as a ligand for the colony-stimulating factor-1 receptor (CSF1R), a receptor known to regulate the survival, proliferation, and differentiation of macrophages and monocytes. IL-34 functions in synergy with macrophage colony-stimulating factor (M-CSF or CSF1), which is another ligand for CSF1R, to regulate immune system homeostasis. IL-34 is secreted by several cell types, including fibroblasts, keratinocytes, neuronal cells, and epithelial cells, and is expressed across different tissues, particularly in the spleen, brain, and kidneys. The broad tissue distribution of IL-34 underscores its involvement in immune modulation in diverse physiological contexts, including neuroinflammation, autoimmune diseases, and cancer. Its role is central to macrophage biology, impacting innate immune responses, tissue repair, and inflammatory processes.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Interleukin 34 (IL34)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 31.2 kDa Observed MW: 31 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Met1-Pro242 Tag: N-terminal His tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
IL34
dry ice
No
availability
Shipped within 5-7 working days.
alias
IL-34,C16orf77
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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