Human Interleukin 23 (IL23) Protein

Este producto es parte de IL23A - interleukin 23 subunit alpha
Human Interleukin 23 (IL23) Protein

Pida mas información

935106861

info@markelab.com

Precio

260€ (10 µg)

Protein IL23A

proveedor

Abbexa

reference

abx067509

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Recombinant Interleukin 23 (IL23) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

Interleukin 23A (IL23A), also referred to as IL-23, is a heterodimeric cytokine that plays a pivotal role in immune regulation, inflammation, and host defense. It is a member of the IL-12 cytokine family, which is integral to bridging the innate and adaptive immune systems. IL-23 is predominantly produced by antigen-presenting cells (such as dendritic cells and macrophages) and acts mainly on T cells, specifically promoting the differentiation, expansion, and maintenance of Th17 cells. IL-23 is essential for chronic inflammation and has been implicated in several autoimmune and inflammatory diseases, including psoriasis, rheumatoid arthritis (RA), Crohn’s disease, and multiple sclerosis (MS). Unlike its close relative IL-12, which promotes Th1 responses and interferon-γ (IFN-γ) production, IL-23 plays a critical role in the IL-23/Th17 axis, influencing the production of IL-17 and other pro-inflammatory cytokines that contribute to tissue inflammation

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Interleukin 23 (IL23)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 19.9 kDa Observed MW (SDS-PAGE): 15/16 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Arg20-Pro189 Tag: N-terminal His tag


expression

Recombinant


purity

> 90%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

IL23A


dry ice

No


availability

Shipped within 5-7 working days.


alias

P19,SGRF,IL-23,L-23A,IL23P19,L-23 subunit alpha,IL-23-A,Interleukin-23 subunit p19 IL-23p19


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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