Human Interleukin 20 (IL20) Protein

Background

Interleukin 20 (IL20) is a member of the IL-10 cytokine family, which includes structurally related cytokines like IL-19, IL-22, IL-24, and IL-26. These cytokines share common biological functions in regulating immune responses, inflammation, and tissue homeostasis. IL-20, in particular, is predominantly associated with the modulation of skin, lung, and other epithelial tissues, where it exerts its effects on inflammation, tissue repair, and the innate immune response. IL-20 is produced by various cell types, including monocytes, keratinocytes, endothelial cells, and fibroblasts. Its expression is induced by pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α, particularly in tissues experiencing inflammation or injury. IL-20 acts primarily on epithelial and immune cells to regulate tissue homeostasis and inflammation, making it an important mediator in diseases like psoriasis, rheumatoid arthritis, and pulmonary inflammation.