Human Interleukin 2 Receptor, Gamma (IL2RG) Protein

Este producto es parte de IL2RG - interleukin 2 receptor subunit gamma
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247€ (10 µg)

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935106861
info@markelab.com
name
Human Interleukin 2 Receptor, Gamma (IL2RG) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx067501
tested applications
WB, SDS-PAGE

Description

Recombinant Interleukin 2 Receptor Gamma (IL2Rg) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Interleukin 2 Receptor, Gamma (IL2RG)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 29.5 kDa  Observed MW (SDS-PAGE): 29 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Leu23-Ala262

Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P31785
Alias
Cytokine receptor common subunit gamma,P64,CIDX,IMD4,CD132,SCIDX,IL-2RG,SCIDX1,IL-2 receptor subunit gamma,IL-2R subunit gamma
Background
Protein IL2RG
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

The Interleukin 2 Receptor Subunit Gamma (IL2RG), also known as the common gamma chain or γc, is a crucial component of several cytokine receptor complexes, specifically those for interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Each of these cytokines plays a vital role in immune cell development, activation, and homeostasis. Because IL2RG is part of multiple cytokine receptor systems, it is often referred to as a "common" subunit, essential for the signaling functionality of these cytokines. The expression of IL2RG is indispensable for immune competence, influencing processes in adaptive immunity and innate immune responses. In its absence, severe immunodeficiency conditions, such as X-linked severe combined immunodeficiency (X-SCID), can occur, indicating its role in T cell, B cell, and natural killer (NK) cell development. IL2RG does not directly bind to cytokines but facilitates signal transduction by forming a complex with cytokine-specific receptor subunits and initiating intracellular signaling cascades. The signaling through IL2RG activates critical pathways, including JAK/STAT, MAPK, and PI3K/AKT, which are integral to immune cell differentiation, proliferation, and survival. Due to the centrality of IL2RG in immune system function, mutations in this gene have severe implications for immune cell functionality and host defense.

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