Human Interleukin 2 Receptor, Gamma (IL2RG) ELISA Kit
643.5€ (96 tests)
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name
Human Interleukin 2 Receptor, Gamma (IL2RG) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx151944
tested applications
ELISA
Description
Human Interleukin 2 Receptor, Gamma (IL2RG) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Interleukin 2 Receptor, Gamma (IL2RG) concentrations in serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Interleukin 2 Receptor Gamma (IL2Rg)
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Interleukin 2 Receptor, Gamma (IL2RG) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.06 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, tissue homogenates, cell lysates, cell culture supernatants and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | Cytokine receptor common subunit gamma,P64,CIDX,IMD4,CD132,SCIDX,IL-2RG,SCIDX1,IL-2 receptor subunit gamma,IL-2R subunit gamma |
| Background | Elisa kits for IL2RG |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
The Interleukin 2 Receptor Subunit Gamma (IL2RG), also known as the common gamma chain or γc, is a crucial component of several cytokine receptor complexes, specifically those for interleukin-2 (IL-2), IL-4, IL-7, IL-9, IL-15, and IL-21. Each of these cytokines plays a vital role in immune cell development, activation, and homeostasis. Because IL2RG is part of multiple cytokine receptor systems, it is often referred to as a "common" subunit, essential for the signaling functionality of these cytokines. The expression of IL2RG is indispensable for immune competence, influencing processes in adaptive immunity and innate immune responses. In its absence, severe immunodeficiency conditions, such as X-linked severe combined immunodeficiency (X-SCID), can occur, indicating its role in T cell, B cell, and natural killer (NK) cell development. IL2RG does not directly bind to cytokines but facilitates signal transduction by forming a complex with cytokine-specific receptor subunits and initiating intracellular signaling cascades. The signaling through IL2RG activates critical pathways, including JAK/STAT, MAPK, and PI3K/AKT, which are integral to immune cell differentiation, proliferation, and survival. Due to the centrality of IL2RG in immune system function, mutations in this gene have severe implications for immune cell functionality and host defense.
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Interleukin 2 Receptor, Gamma (IL2RG) Antibody
IL2RG Antibody is a Rabbit Polyclonal antibody against IL2RG. The protein encoded by this gene is an important signaling component of many interleukin receptors, including those of interleukin -2, -4, -7 and -21, and is thus referred to as the common gamma chain. Mutations in this gene cause X-linked severe combined immunodeficiency (XSCID), as well as X-linked combined immunodeficiency (XCID), a less severe immunodeficiency disorder. [provided by RefSeq, Mar 2010].
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