Human Interleukin 18 Receptor Accessory Protein (IL18RAP) Protein
208€ (10 µg)
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name
Human Interleukin 18 Receptor Accessory Protein (IL18RAP) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx690143
tested applications
SDS-PAGE
Description
Human IL-18 Receptor Accessory Protein is a recombinant Human protein expressed in Human Cells. The target gene encoding Phe20-Arg356 is expressed with a 6x His tag at the C-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | IL-18 Receptor Accessory |
| Host | Human |
| Origin | Human |
| Observed MW | Molecular Weight: Calculated MW: 39.4 kDa Observed MW (SDS-PAGE): 56 kDa Sequence Fragment: Phe20-Arg356 Tag: C-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Purification | Sterile filtered (0.2 µm) prior to lyophilization. |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Lyophilized Reconstitute in sterile distilled water to a concentration of 0.25 mg/ml. Do not vortex. |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store lyophilized at or below -20 °C. Upon reconstitution, store between 4-7 °C for up to 7 days, or aliquot and store at or below -20 °C for up to 3 months. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O95256 |
| Alias | IL18RAP, ACPL, CD218b, CDw218b, IL-18R-beta, IL-18Rbeta, IL18RB, IL-1 R7,IL1R7 |
| Background | Protein IL18RAP |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
IL18RAP is an essential co-receptor that forms a heterodimeric complex with IL18R1 to enable IL-18-mediated immune signaling. It enhances the binding affinity of IL-18 to IL18R1, facilitating the recruitment of MyD88 and the activation of downstream signaling pathways, including NF-κB and MAPK, which drive the production of pro-inflammatory cytokines such as IFN-γ. IL18RAP is highly expressed on immune cells such as NK cells, macrophages, and Th1 T cells, where it regulates immune activation, cytokine release, and pathogen defense. It plays a pivotal role in promoting inflammation, antiviral immunity, and anti-tumor responses by enhancing IL-18 signaling efficiency. Dysregulation of IL18RAP is associated with inflammatory diseases, autoimmune disorders, and cancers, where aberrant IL-18 signaling exacerbates tissue damage and immune dysregulation. Functional studies show that loss of IL18RAP impairs IL-18 signaling, reduces cytokine production, and weakens immune responses, highlighting its critical role as a signaling cofactor in inflammation, immune defense, and disease progression.
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