Human Interleukin 18 Receptor Accessory Protein (IL18RAP) Protein
221€ (10 µg)
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935106861
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name
Human Interleukin 18 Receptor Accessory Protein (IL18RAP) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166187
tested applications
WB, SDS-PAGE
Description
Interleukin 18 Receptor Accessory Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Interleukin 18 Receptor Accessory Protein (IL18RAP) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 48.7 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu310-Ser451 Tag: N-terminal His tag and GST tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q3KPE8 |
| Alias | IL18RAP, ACPL, CD218b, CDw218b, IL-18R-beta, IL-18Rbeta, IL18RB, IL-1 R7,IL1R7 |
| Background | Protein IL18RAP |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
IL18RAP is an essential co-receptor that forms a heterodimeric complex with IL18R1 to enable IL-18-mediated immune signaling. It enhances the binding affinity of IL-18 to IL18R1, facilitating the recruitment of MyD88 and the activation of downstream signaling pathways, including NF-κB and MAPK, which drive the production of pro-inflammatory cytokines such as IFN-γ. IL18RAP is highly expressed on immune cells such as NK cells, macrophages, and Th1 T cells, where it regulates immune activation, cytokine release, and pathogen defense. It plays a pivotal role in promoting inflammation, antiviral immunity, and anti-tumor responses by enhancing IL-18 signaling efficiency. Dysregulation of IL18RAP is associated with inflammatory diseases, autoimmune disorders, and cancers, where aberrant IL-18 signaling exacerbates tissue damage and immune dysregulation. Functional studies show that loss of IL18RAP impairs IL-18 signaling, reduces cytokine production, and weakens immune responses, highlighting its critical role as a signaling cofactor in inflammation, immune defense, and disease progression.
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