Human Interleukin 18 Receptor Accessory Protein (IL18RAP) Protein
Pida mas información
935106861
info@markelab.com
Precio
221€ (10 µg)
Protein IL18RAP
proveedor
Abbexareference
abx166187Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Interleukin 18 Receptor Accessory Protein is a recombinant Human protein expressed in E. coli.
Background
IL18RAP is an essential co-receptor that forms a heterodimeric complex with IL18R1 to enable IL-18-mediated immune signaling. It enhances the binding affinity of IL-18 to IL18R1, facilitating the recruitment of MyD88 and the activation of downstream signaling pathways, including NF-κB and MAPK, which drive the production of pro-inflammatory cytokines such as IFN-γ. IL18RAP is highly expressed on immune cells such as NK cells, macrophages, and Th1 T cells, where it regulates immune activation, cytokine release, and pathogen defense. It plays a pivotal role in promoting inflammation, antiviral immunity, and anti-tumor responses by enhancing IL-18 signaling efficiency. Dysregulation of IL18RAP is associated with inflammatory diseases, autoimmune disorders, and cancers, where aberrant IL-18 signaling exacerbates tissue damage and immune dysregulation. Functional studies show that loss of IL18RAP impairs IL-18 signaling, reduces cytokine production, and weakens immune responses, highlighting its critical role as a signaling cofactor in inflammation, immune defense, and disease progression.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Interleukin 18 Receptor Accessory Protein (IL18RAP)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 48.7 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Leu310-Ser451 Tag: N-terminal His tag and GST tag
expression
Recombinant
purity
> 95%
buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
IL18RAP
dry ice
No
availability
Shipped within 5-7 working days.
alias
IL18RAP, ACPL, CD218b, CDw218b, IL-18R-beta, IL-18Rbeta, IL18RB, IL-1 R7,IL1R7
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
Quizá le pueda interesar
Interleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
proveedor
Abbexareference
abx034109Tested Applications
ELISA, WB, IHC, FCMreactivity
Humanstatus
RUOclonality
PolyclonalIL18RAP is required for the high affinity binding of interleukin 18 (IL-18) to its receptor complex (By similarity). Tog...
292.5€ (80 µl)
Ver másInterleukin 18 Receptor Accessory Protein (IL18RAP) Antibody
proveedor
Abbexareference
abx037127Tested Applications
ELISA, WBreactivity
Humanstatus
RUOclonality
PolyclonalRabbit Polyclonal against the IL18RAP protein.
357.5€ (100 µg)
Ver másMouse Interleukin 18 Receptor Accessory Protein (IL18RAP) Protein
proveedor
Abbexareference
abx067490Tested Applications
WB, SDS-PAGEstatus
RUORecombinant Interleukin 18 Receptor Accessory Protein (IL18RAP) is a recombinant Mouse protein produced in a Prokaryotic...
247€ (10 µg)
Ver más