Human Interleukin 18 Receptor Accessory Protein (IL18RAP) ELISA Kit
689€ (96 tests)
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935106861
info@markelab.com
name
Human Interleukin 18 Receptor Accessory Protein (IL18RAP) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx151931
tested applications
ELISA
Description
Human Interleukin 18 Receptor Accessory Protein (IL18RAP) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Interleukin 18 Receptor Accessory Protein (IL18RAP) concentrations in tissue homogenates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Interleukin 18 Receptor Accessory Protein (IL18RAP)
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Interleukin 18 Receptor Accessory Protein (IL18RAP) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.06 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates and other biological fluids. |
| Availability | Shipped within 5-7 working days. The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | IL18RAP, ACPL, CD218b, CDw218b, IL-18R-beta, IL-18Rbeta, IL18RB, IL-1 R7,IL1R7 |
| Background | Elisa kits for IL18RAP |
| Status | RUO |
| Note | Validity: The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
IL18RAP is an essential co-receptor that forms a heterodimeric complex with IL18R1 to enable IL-18-mediated immune signaling. It enhances the binding affinity of IL-18 to IL18R1, facilitating the recruitment of MyD88 and the activation of downstream signaling pathways, including NF-κB and MAPK, which drive the production of pro-inflammatory cytokines such as IFN-γ. IL18RAP is highly expressed on immune cells such as NK cells, macrophages, and Th1 T cells, where it regulates immune activation, cytokine release, and pathogen defense. It plays a pivotal role in promoting inflammation, antiviral immunity, and anti-tumor responses by enhancing IL-18 signaling efficiency. Dysregulation of IL18RAP is associated with inflammatory diseases, autoimmune disorders, and cancers, where aberrant IL-18 signaling exacerbates tissue damage and immune dysregulation. Functional studies show that loss of IL18RAP impairs IL-18 signaling, reduces cytokine production, and weakens immune responses, highlighting its critical role as a signaling cofactor in inflammation, immune defense, and disease progression.
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