Human Interleukin-12 Subunit Alpha (IL12A) Protein
253.5€ (10 µg)
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935106861
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name
Human Interleukin-12 Subunit Alpha (IL12A) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx060175
tested applications
HPLC, SDS-PAGE
Description
Human IL-12 Protein is a recombinant protein from E. Coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | IL12 |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: 75 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Form | Lyophilized Reconstitute with sterile 18MΩ-cm H2O. |
| Tested Applications | HPLC, SDS-PAGE |
| Buffer | 10 mM phosphate buffer, 200 mM NaCl (pH 7.0). Does not contain preservatives. |
| Availability | Shipped within 5-10 working days. |
| Storage | Store at -20°C or -80°C for 2 years. After reconstituting, it can be stored at 4°C for a week, it is recommended to add 0.1% HSA or BSA for long term. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P29459 |
| Gene ID | 3593 |
| OMIM | 161560 |
| Alias | P35,CLMF,NFSK,NKSF1,IL-12A,Cytotoxic lymphocyte maturation factor 35 kDa subunit,CLMF p35,IL-12 subunit p35,NK cell stimulatory factor chain 1 |
| Background | Protein IL12A |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Interleukin 12A (IL12A) is a subunit of the heterodimeric cytokine interleukin-12, which plays a pivotal role in the immune system by bridging innate and adaptive immunity. IL12A, also known as IL-12p35, pairs with the IL12B subunit (IL-12p40) to form the active cytokine IL-12, which is essential for inducing T-helper 1 (Th1) immune responses. IL12A is produced by activated antigen-presenting cells, such as macrophages and dendritic cells, in response to infections or immune challenges. It functions by stimulating natural killer (NK) cells and CD4+ T-cells to produce interferon-gamma (IFN-γ), a cytokine critical for pathogen clearance and enhancing cytotoxic activities. Dysregulation of IL12A expression has been associated with autoimmune diseases, chronic inflammation, and cancer. Therapeutic strategies targeting IL12A, including IL-12 inhibitors or engineered cytokines, are being explored for managing these conditions and for enhancing anti-tumor immune responses.
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