Human Interleukin 1 Receptor Type I (IL1R1) CLIA Kit
643.5€ (96 tests)
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name
Human Interleukin 1 Receptor Type I (IL1R1) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx195874
tested applications
CLIA
Description
Human Interleukin 1 Receptor Type I (IL1R1) Chemiluminescent Immunoassay (CLIA) Kit is a Chemiluminescent Immunoassay (CLIA) kit against Interleukin 1 Receptor Type I (IL1R1).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Interleukin 1 Receptor Type I (IL1R1) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Test Range | 31.2 pg/ml - 2000 pg/ml |
| Sensitivity | 18.8 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Serum, plasma and other biological fluids. |
| Availability | Shipped within 5-12 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | IL1R1,CD121a, IL1 RI |
| Background | CLIA Kits IL1R1 |
| Status | RUO |
| Note | The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
IL1R1 is a transmembrane receptor that belongs to the interleukin-1 receptor family and plays a central role in mediating pro-inflammatory signaling IL1R1 binds to interleukin-1α (IL-1α), interleukin-1β (IL-1β), and the IL-1 receptor antagonist (IL-1Ra), forming a receptor complex with the IL-1 receptor accessory protein (IL1RAP) to initiate downstream signaling Upon ligand binding, IL1R1 activates intracellular pathways such as nuclear factor kappa B (NF-κB) and mitogen-activated protein kinases (MAPKs), leading to the expression of pro-inflammatory cytokines, chemokines, and adhesion molecules IL1R1 is expressed on various immune and non-immune cells, including macrophages, fibroblasts, and epithelial cells, where it mediates immune responses to infection, injury, and inflammation Dysregulation of IL1R1 signaling is implicated in chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and systemic lupus erythematosus IL1R1 is also a target for anti-inflammatory therapies, including drugs like anakinra, which block IL-1 binding to reduce inflammation and disease progression
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