Human Interleukin-1 Receptor-Like 2 (IL1RL2) Protein
273€ (10 µg)
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Name
Human Interleukin-1 Receptor-Like 2 (IL1RL2) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx691290
Tested Applications
SDS-PAGE
Description
Interleukin-1 Receptor-Like 2 (IL1RL2) protein is a recombinant Human protein expressed in HEK293 cells.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | Interleukin-1 Receptor-Like 2 (IL1RL2) |
| Host | HEK293 cells |
| Assay Type | Activity: Not tested Sequence Fragment: Asp20-Tyr337 Tag: C-terminal Fc tag |
| Origin | Human |
| Observed MW | Calculated MW: 63.1 kDa Observed MW (SDS-PAGE): 80-110 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Purification | 0.2 µm filtered prior to lyophilization. |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 5%-8% Trehalose, Mannitol and 0.01% Tween 80. |
| Availability | Shipped within 5-15 working days. |
| Storage | Storage: Store lyophilized between -20 °C and -80°C. Stability: Stable when stored reconstituted at 2-8°C for up to 1 week. Reconstituted aliquots are stable at -20°C for up to 3 months. Shelf Life: 12 months. |
| Dry Ice | No |
| UniProt ID | Q9HB29 |
| Gene ID | 8808 |
| OMIM | 604512 |
| Alias | IL1RL2, IL-1Rrp2, IL-36R, IL1R-rp2, IL1RRP2, IL-1R6 |
| Background | Protein IL1RL2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in sterile H2O to prepare a stock solution of concentration 0.25 mg/ml. Do not vortex. Endotoxin Level: < 1.0 EU per µg (LAL method). |
Background
IL1RL2, also known as IL-36 receptor, is a key component of the interleukin-1 receptor (IL-1R) family, mediating IL-36 cytokine signaling to regulate inflammatory and immune responses. IL1RL2 forms a heterodimeric complex with the IL-1 receptor accessory protein (IL1RAP) upon IL-36 ligand binding, leading to the recruitment of MyD88, which activates downstream NF-κB, MAPK, and JNK signaling pathways. These pathways promote the production of pro-inflammatory cytokines and chemokines such as IL-6, TNF-α, and CXCL1, driving immune cell activation and tissue inflammation. IL1RL2 is predominantly expressed in epithelial cells, immune cells, and tissues like the skin and lungs, where it plays essential roles in host defense against infections and the regulation of inflammation. Dysregulation of IL1RL2 has been implicated in inflammatory diseases such as psoriasis, inflammatory bowel disease, and rheumatoid arthritis, where excessive IL-36 signaling exacerbates tissue damage and chronic inflammation. Knockdown studies reveal impaired IL-36 signaling, reduced cytokine production, and decreased immune activation, highlighting its critical role in inflammation, epithelial immunity, and disease pathogenesis.
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