Human Interleukin-1 Receptor-Like 2 (IL1RL2) ELISA Kit
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Description
Human Interleukin-1 Receptor-Like 2 (IL1RL2) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Interleukin-1 Receptor-Like 2 (IL1RL2) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Interleukin-1 Receptor-Like 2 (IL1RL2) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.313 ng/ml - 20 ng/ml |
| Sensitivity | < 0.188 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9HB29 |
| Gene ID | 8808 |
| OMIM | 604512 |
| Alias | IL1RL2, IL-1Rrp2, IL-36R, IL1R-rp2, IL1RRP2, IL-1R6 |
| Background | Elisa kits for IL1RL2 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
IL1RL2, also known as IL-36 receptor, is a key component of the interleukin-1 receptor (IL-1R) family, mediating IL-36 cytokine signaling to regulate inflammatory and immune responses. IL1RL2 forms a heterodimeric complex with the IL-1 receptor accessory protein (IL1RAP) upon IL-36 ligand binding, leading to the recruitment of MyD88, which activates downstream NF-κB, MAPK, and JNK signaling pathways. These pathways promote the production of pro-inflammatory cytokines and chemokines such as IL-6, TNF-α, and CXCL1, driving immune cell activation and tissue inflammation. IL1RL2 is predominantly expressed in epithelial cells, immune cells, and tissues like the skin and lungs, where it plays essential roles in host defense against infections and the regulation of inflammation. Dysregulation of IL1RL2 has been implicated in inflammatory diseases such as psoriasis, inflammatory bowel disease, and rheumatoid arthritis, where excessive IL-36 signaling exacerbates tissue damage and chronic inflammation. Knockdown studies reveal impaired IL-36 signaling, reduced cytokine production, and decreased immune activation, highlighting its critical role in inflammation, epithelial immunity, and disease pathogenesis.
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