Human Intelectin 1 (ITLN1) Protein
234€ (2 µg)
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Name
Human Intelectin 1 (ITLN1) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx262977
Tested Applications
SDS-PAGE
Description
Human ITLN1 Protein is a recombinant cytokine expressed in E. coli.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | ITLN1 |
| Host | E. coli |
| Assay Type | Activity: Not tested Sequence Fragment: 313 AA. |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | 35 kDa |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Purification | Purified by proprietary chromatographic techniques. |
| Size 1 | 2 µg |
| Size 2 | 10 µg |
| Size 3 | 1 mg |
| Form | Lyophilized |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: 10 mM NaP, pH 7.5, and 5:1 mannitol to protein. |
| Availability | Shipped within 5-10 working days. |
| Storage | Stable at room temperature for up to 3 weeks. It is recommended to store this product desiccated at or below -18°C. After reconstitution, store at 4°C for short-term storage (up to 7 days) or below -18°C for long-term storage. For long-term storage, it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8WWA0 |
| Alias | HL1,LFR,HL-1,INTL,ITLN,hIntL,omentin |
| Background | Protein ITLN1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. Reconstitute in sterile 18 MΩ · cm water to a concentration of at least 100 µg/ml. This stock solution can be further diluted if required. |
Background
ITLN1 is a secreted glycoprotein mainly expressed in adipose tissue, the small intestine, and the mesothelial cells It is known for its role in immune defense by binding to pathogen-associated carbohydrate structures, such as galactofuranose residues on microbial surfaces ITLN1 also acts as an adipokine, influencing insulin sensitivity and glucose metabolism through its association with obesity and metabolic diseases Decreased ITLN1 levels are linked to insulin resistance, type 2 diabetes, and obesity, while elevated levels are observed under conditions like calorie restriction or weight loss ITLN1 exerts anti-inflammatory and anti-oxidative effects, improving metabolic function by reducing inflammatory cytokine production and enhancing insulin signaling in skeletal muscle It is also involved in tissue repair and epithelial protection through its interaction with epithelial cell surfaces Dysregulation of ITLN1 expression is associated with cardiovascular diseases and inflammatory disorders, making it a potential therapeutic target for obesity-related metabolic dysfunction
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