Human Intelectin 1 (ITLN1) Protein

Este producto es parte de ITLN - Intelectin (Omentin)
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221€ (10 µg)

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935106861
info@markelab.com
name
Human Intelectin 1 (ITLN1) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx067298
tested applications
WB, SDS-PAGE

Description

Human ITLN1 is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
Intelectin 1 (ITLN1)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 28.4 kDa  Observed MW (SDS-PAGE): 28 kDa

Concentration: Prior to lyophilization: 200 µg/ml

Sequence Fragment: Cys31-Gly253

Tag: N-terminal His tag
Expression
Recombinant
Purity
> 90%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q8WWA0
Alias
HL1,LFR,HL-1,INTL,ITLN,hIntL,omentin
Background
Protein ITLN1
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

ITLN1 is a secreted glycoprotein mainly expressed in adipose tissue, the small intestine, and the mesothelial cells It is known for its role in immune defense by binding to pathogen-associated carbohydrate structures, such as galactofuranose residues on microbial surfaces ITLN1 also acts as an adipokine, influencing insulin sensitivity and glucose metabolism through its association with obesity and metabolic diseases Decreased ITLN1 levels are linked to insulin resistance, type 2 diabetes, and obesity, while elevated levels are observed under conditions like calorie restriction or weight loss ITLN1 exerts anti-inflammatory and anti-oxidative effects, improving metabolic function by reducing inflammatory cytokine production and enhancing insulin signaling in skeletal muscle It is also involved in tissue repair and epithelial protection through its interaction with epithelial cell surfaces Dysregulation of ITLN1 expression is associated with cardiovascular diseases and inflammatory disorders, making it a potential therapeutic target for obesity-related metabolic dysfunction

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