Human Integrin Beta III / CD61 (ITGB3) Protein

Este producto es parte de ITGB3 - integrin subunit beta 3
Human Integrin Beta III / CD61 (ITGB3) Protein

Pida mas información

935106861

info@markelab.com

Precio

195€ (10 µg)

Protein ITGB3

proveedor

Abbexa

reference

abx067294

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Human Integrin Beta 3 (ITGb3) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).


Background

ITGB3 (Integrin Subunit Beta 3) encodes the β3 subunit of integrins, which are transmembrane receptors that mediate cell-cell and cell-extracellular matrix (ECM) interactions. Integrins are essential in diverse cellular processes, including cell adhesion, migration, signal transduction, immune responses, and angiogenesis. The ITGB3 protein partners with αIIb (encoded by ITGA2B) and αV (encoded by ITGAV) to form αIIbβ3 and αVβ3 integrins, respectively. These heterodimers are pivotal for platelet aggregation, thrombosis, wound healing, and interactions with extracellular matrix proteins like fibrinogen, fibronectin, and vitronectin. ITGB3 is expressed in platelets, endothelial cells, and various tissues involved in cell movement and immune responses. Dysregulation or mutation of ITGB3 can lead to disorders such as Glanzmann thrombasthenia, affecting platelet function, or it can play a role in pathological conditions like cancer metastasis, where altered cell adhesion and migration are key.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Integrin Beta III / CD61 (ITGB3)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 33.8 kDa Observed MW (SDS-PAGE): 34 kDa Concentration: Prior to lyophilization: 2000 µg/ml Sequence Fragment: Asp135-Ile377 Tag: N-terminal His tag


expression

Recombinant


purity

> 97%


buffer

Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ITGB3


dry ice

No


availability

Shipped within 5-7 working days.


alias

GT,GT2,CD61,GP3A,BDPLT2,GPIIIa,BDPLT16,BDPLT24,Integrin beta-3,Platelet membrane glycoprotein IIIa 


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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