Human Integrin Beta III / CD61 (ITGB3) Protein
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935106861
info@markelab.com
Precio
195€ (10 µg)
Protein ITGB3
proveedor
Abbexareference
abx067294Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Integrin Beta 3 (ITGb3) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Background
ITGB3 (Integrin Subunit Beta 3) encodes the β3 subunit of integrins, which are transmembrane receptors that mediate cell-cell and cell-extracellular matrix (ECM) interactions. Integrins are essential in diverse cellular processes, including cell adhesion, migration, signal transduction, immune responses, and angiogenesis. The ITGB3 protein partners with αIIb (encoded by ITGA2B) and αV (encoded by ITGAV) to form αIIbβ3 and αVβ3 integrins, respectively. These heterodimers are pivotal for platelet aggregation, thrombosis, wound healing, and interactions with extracellular matrix proteins like fibrinogen, fibronectin, and vitronectin. ITGB3 is expressed in platelets, endothelial cells, and various tissues involved in cell movement and immune responses. Dysregulation or mutation of ITGB3 can lead to disorders such as Glanzmann thrombasthenia, affecting platelet function, or it can play a role in pathological conditions like cancer metastasis, where altered cell adhesion and migration are key.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Integrin Beta III / CD61 (ITGB3)
host
E. coli
conjugation
Unconjugated
form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 33.8 kDa Observed MW (SDS-PAGE): 34 kDa Concentration: Prior to lyophilization: 2000 µg/ml Sequence Fragment: Asp135-Ile377 Tag: N-terminal His tag
expression
Recombinant
purity
> 97%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ITGB3
dry ice
No
availability
Shipped within 5-7 working days.
alias
GT,GT2,CD61,GP3A,BDPLT2,GPIIIa,BDPLT16,BDPLT24,Integrin beta-3,Platelet membrane glycoprotein IIIa
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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