Human Integrin Beta III / CD61 (ITGB3) Protein
195€ (10 µg)
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name
Human Integrin Beta III / CD61 (ITGB3) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx067294
tested applications
WB, SDS-PAGE
Description
Human Integrin Beta 3 (ITGb3) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Integrin Beta III / CD61 (ITGB3) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 33.8 kDa Observed MW (SDS-PAGE): 34 kDa Concentration: Prior to lyophilization: 2000 µg/ml Sequence Fragment: Asp135-Ile377 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 97% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 10 mM PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in 10 mM PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM EDTA, 1 mM DTT, 0.01% Sarcosyl, 5% Trehalose. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P05106 |
| Alias | GT,GT2,CD61,GP3A,BDPLT2,GPIIIa,BDPLT16,BDPLT24,Integrin beta-3,Platelet membrane glycoprotein IIIa |
| Background | Protein ITGB3 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
ITGB3 (Integrin Subunit Beta 3) encodes the β3 subunit of integrins, which are transmembrane receptors that mediate cell-cell and cell-extracellular matrix (ECM) interactions. Integrins are essential in diverse cellular processes, including cell adhesion, migration, signal transduction, immune responses, and angiogenesis. The ITGB3 protein partners with αIIb (encoded by ITGA2B) and αV (encoded by ITGAV) to form αIIbβ3 and αVβ3 integrins, respectively. These heterodimers are pivotal for platelet aggregation, thrombosis, wound healing, and interactions with extracellular matrix proteins like fibrinogen, fibronectin, and vitronectin. ITGB3 is expressed in platelets, endothelial cells, and various tissues involved in cell movement and immune responses. Dysregulation or mutation of ITGB3 can lead to disorders such as Glanzmann thrombasthenia, affecting platelet function, or it can play a role in pathological conditions like cancer metastasis, where altered cell adhesion and migration are key.
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The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface mediated signalling.
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