Human Integrin Beta 2 (ITGB2) Protein
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935106861
info@markelab.com
Precio
221€ (10 µg)
Protein ITGB2
proveedor
Abbexareference
abx166642Tested Applications
WB, SDS-PAGEreactivity
status
RUOclonality
Descripción
Human Integrin Beta 2 Protein is a recombinant Human protein expressed in E. coli.
Background
ITGB2, or integrin subunit beta 2, is a protein that plays a central role in leukocyte adhesion and signaling, facilitating the immune system's response to infections and inflammation. ITGB2, also known as CD18, is part of the integrin family, which consists of transmembrane receptors involved in cell-cell and cell-extracellular matrix (ECM) interactions. Integrins are heterodimeric proteins formed by the association of alpha (α) and beta (β) subunits. In particular, ITGB2 pairs with various alpha integrin subunits to form key receptors known as beta-2 integrins. Beta-2 integrins are primarily expressed on leukocytes (white blood cells) and are essential for mediating cell adhesion, migration, phagocytosis, and immune surveillance. The four major integrins that involve ITGB2 are LFA-1 (αLβ2, CD11a/CD18), Mac-1 (αMβ2, CD11b/CD18), gp150/95 (αXβ2, CD11c/CD18), and αDβ2 (CD11d/CD18). These integrins are vital for the immune system's ability to respond to infections and regulate inflammation.
Características del producto
category
Proteins and Peptides
origin
Human
host
E. coli
immunogen target
Integrin Beta 2 (ITGB2)
host
E. coli
conjugation
Unconjugated
form
Lyophilized Reconstitute in ddH2O to a concentration up to 0.5 mg/ml. Do not vortex.
tested applications
WB, SDS-PAGE
size 1
10 µg
size 2
50 µg
size 3
100 µg
size 4
200 µg
size 5
500 µg
observerd MW
Molecular Weight: Calculated MW: 69.1 kDa Observed MW (SDS-PAGE): 70 kDa Concentration: Prior to lyophilization: 50 µg/ml Sequence Fragment: Asp451-Ser627 Tag: N-terminal His tag and MBP tag
expression
Recombinant
purity
> 97%
buffer
Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 0.01% Sarcosyl, 5% Trehalose.
storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
or code
ITGB2
dry ice
No
availability
Shipped within 5-7 working days.
alias
LAD,CD18,MF17,MFI7,LCAMB,LFA-1,MAC-1,Integrin beta-2,Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta,Complement receptor C3 subunit beta
uniprot id
note
This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.
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