Human Leukocyte Surface Antigen CD47 (CD47) Protein
234€ (2 µg)
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name
Human Leukocyte Surface Antigen CD47 (CD47) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx680444
tested applications
SDS-PAGE
Description
Human Leukocyte Surface Antigen CD47 (CD47) Protein is a recombinant protein produced in Sf9, Baculovirus cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Leukocyte Surface Antigen CD47 (CD47) |
| Host | Insect |
| Origin | Human |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 2 µg |
| Size 2 | 10 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| Alias | IAP,OA3,MER6,Antigenic surface determinant protein OA3,Integrin-associated protein, |
| Background | Protein CD47 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
CD47, also known as integrin-associated protein (IAP), is a widely expressed transmembrane glycoprotein that plays a critical role in immune regulation, cell signaling, and cellular adhesion. It is a member of the immunoglobulin superfamily and is involved in numerous biological processes, including immune evasion, apoptosis, angiogenesis, and cell migration. One of CD47's primary functions is to act as a "don't eat me" signal to prevent macrophage-mediated phagocytosis, which is a key component in the immune system's ability to clear dead cells and pathogens. CD47 interacts with signal regulatory protein alpha (SIRPα), a receptor primarily expressed on myeloid cells, such as macrophages and dendritic cells. The binding of CD47 to SIRPα sends an inhibitory signal to macrophages, preventing the phagocytosis of CD47-expressing cells. This interaction plays a critical role in protecting normal cells from immune clearance but can also be exploited by cancer cells to evade immune detection and destruction.
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