Human Leukocyte Surface Antigen CD47 (CD47) ELISA Kit
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935106861
info@markelab.com
Precio
662.5€ (96 tests)
Elisa Kits CD47
proveedor
Abbexareference
abx151889Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Integrin Associated Protein / IAP (CD47) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Integrin Associated Protein / IAP (CD47) concentrations in tissue homogenates, cell lysates and other biological fluids. This assay has high sensitivity and excellent specificity for detection of Integrin Associated Protein / IAP (CD47)No significant cross-reactivity or interference between Integrin Associated Protein / IAP (CD47) and analogues was observed.
Background
CD47, also known as integrin-associated protein (IAP), is a widely expressed transmembrane glycoprotein that plays a critical role in immune regulation, cell signaling, and cellular adhesion. It is a member of the immunoglobulin superfamily and is involved in numerous biological processes, including immune evasion, apoptosis, angiogenesis, and cell migration. One of CD47's primary functions is to act as a "don't eat me" signal to prevent macrophage-mediated phagocytosis, which is a key component in the immune system's ability to clear dead cells and pathogens. CD47 interacts with signal regulatory protein alpha (SIRPα), a receptor primarily expressed on myeloid cells, such as macrophages and dendritic cells. The binding of CD47 to SIRPα sends an inhibitory signal to macrophages, preventing the phagocytosis of CD47-expressing cells. This interaction plays a critical role in protecting normal cells from immune clearance but can also be exploited by cancer cells to evade immune detection and destruction.
Características del producto
category
ELISA Kits
immunogen target
Leukocyte Surface Antigen CD47 (CD47)
reactivity
Human
test range
0.312 ng/ml - 20 ng/ml
sensitivity
< 0.13 ng/ml
assay type
Sandwich
assay data
Quantitative
detection method
Colorimetric
sample type
Tissue homogenates,Cell lysates,Other biological fluids
size 1
96 tests
size 2
5 × 96 tests
size 3
10 × 96 tests
alias
IAP,OA3,MER6,Antigenic surface determinant protein OA3,Integrin-associated protein,
storage
Enviado a 4 °C. Una vez recibido, almacene el kit de acuerdo con las instrucciones citadas en el manual del kit
or code
CD47
dry ice
No
uniprot id
note
This product is for research use only. <p></p> The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. <p></p> Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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