Human Integrin Alpha V (ITGaV) Protein
221€ (10 µg)
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name
Human Integrin Alpha V (ITGaV) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx166523
tested applications
WB, SDS-PAGE
Description
Human Integrin alpha-V Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Integrin Alpha V (ITGaV) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 24.0 kDa Observed MW (SDS-PAGE): 24 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Pro560-Trp744 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 97% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in 20 mM Tris, 150 mM NaCl, pH 8.0. If a higher concentration is required, the product can be reconstituted directly in 20 mM Tris, 150 mM NaCl, pH 8.0, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: 20 mM Tris, 150 mM NaCl, pH 8.0, containing 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P06756 |
| Gene ID | 3685 |
| OMIM | 193210 |
| Alias | CD51,MSK8,VNRA,VTNR,Integrin alpha-V,Vitronectin receptor,Vitronectin receptor subunit alpha |
| Background | Protein ITGAV |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Integrin subunit alpha V (ITGAV) is a crucial component of the integrin family, a group of transmembrane receptors involved in cell-cell and cell-extracellular matrix (ECM) interactions. Integrins are heterodimeric proteins composed of alpha (α) and beta (β) subunits that, when combined, form receptors with various functions, primarily in cell adhesion, migration, proliferation, and signal transduction. ITGAV plays a particularly important role in binding to multiple ligands, including vitronectin, fibronectin, osteopontin, and components of the ECM, enabling it to mediate diverse biological processes such as angiogenesis, tissue repair, immune responses, and tumorigenesis. The gene encoding integrin alpha V (ITGAV) is located on chromosome 2q31.1 in humans. ITGAV pairs with several beta subunits (particularly β1, β3, β5, β6, and β8) to form distinct integrin heterodimers, each with unique ligand specificity and biological function. The most well-characterized integrins involving ITGAV are αvβ3, αvβ5, αvβ6, and αvβ8, which play significant roles in processes like wound healing, angiogenesis, and tumor progression.
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