Human Integrin Alpha IIb / CD41 (ITGA2B) Protein

Este producto es parte de ITGA2B - integrin subunit alpha 2b
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221€ (10 µg)

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935106861
info@markelab.com
name
Human Integrin Alpha IIb / CD41 (ITGA2B) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx168064
tested applications
WB, SDS-PAGE

Description

Integrin Alpha 2B Protein is a recombinant Human protein expressed in E. coli.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Integrin Alpha IIb / CD41 (ITGA2B)
Host
E. coli
Origin
Human
Conjugation
Unconjugated
Observed MW
Molecular Weight: Calculated MW: 20.8 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Gln891-Glu1039
Tag: N-terminal His tag
Expression
Recombinant
Purity
> 95%
Size 1
10 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
500 µg
Form
Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.
Tested Applications
WB, SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.
Availability
Shipped within 5-7 working days.
Storage
Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P08514
Alias
GT,GT1,GTA,CD41,GP2B,HPA3,CD41B,GPIIb,BDPLT2,BDPLT16,PPP1R93,Integrin alpha-Iib,GPalpha IIb (GPIIb),Platelet membrane glycoprotein IIb
Background
Protein ITGA2B
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

ITGA2B, also known as integrin alpha 2b or CD41, is a transmembrane glycoprotein that plays a central role in platelet adhesion and aggregation. It is primarily expressed on platelets and megakaryocytes. Together with integrin beta 3 (ITGB3), ITGA2B forms the αIIbβ3 integrin complex (also known as GPIIb/IIIa), which is the most abundant integrin on the surface of platelets and is crucial for blood clot formation (hemostasis). This receptor mediates platelet aggregation by binding to fibrinogen, von Willebrand factor (vWF), fibronectin, and other adhesive proteins during platelet activation. When platelets are stimulated, the αIIbβ3 complex undergoes a conformational change that allows it to bind its ligands and mediate platelet-platelet interactions.

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