Human Integrin Alpha IIb / CD41 (ITGA2B) Protein

Este producto es parte de ITGA2B - integrin subunit alpha 2b
Human Integrin Alpha IIb / CD41 (ITGA2B) Protein

Pida mas información

935106861

info@markelab.com

Precio

221€ (10 µg)

Protein ITGA2B

proveedor

Abbexa

reference

abx168064

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Integrin Alpha 2B Protein is a recombinant Human protein expressed in E. coli.


Background

ITGA2B, also known as integrin alpha 2b or CD41, is a transmembrane glycoprotein that plays a central role in platelet adhesion and aggregation. It is primarily expressed on platelets and megakaryocytes. Together with integrin beta 3 (ITGB3), ITGA2B forms the αIIbβ3 integrin complex (also known as GPIIb/IIIa), which is the most abundant integrin on the surface of platelets and is crucial for blood clot formation (hemostasis). This receptor mediates platelet aggregation by binding to fibrinogen, von Willebrand factor (vWF), fibronectin, and other adhesive proteins during platelet activation. When platelets are stimulated, the αIIbβ3 complex undergoes a conformational change that allows it to bind its ligands and mediate platelet-platelet interactions.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Integrin Alpha IIb / CD41 (ITGA2B)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 20.8 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gln891-Glu1039 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ITGA2B


dry ice

No


availability

Shipped within 5-7 working days.


alias

GT,GT1,GTA,CD41,GP2B,HPA3,CD41B,GPIIb,BDPLT2,BDPLT16,PPP1R93,Integrin alpha-Iib,GPalpha IIb (GPIIb),Platelet membrane glycoprotein IIb


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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