Human Integrin Alpha 2 (ITGa2) Protein
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Description
Integrin Alpha 2 Protein is a recombinant Human protein expressed in E. coli.
Documents del producto
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Integrin Alpha 2 (ITGa2) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 27.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Glu74-Val277 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 95% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P17301 |
| Alias | BR,GPIa,CD49B,HPA-5,VLA-2,VLAA2,CD49 antigen-like family member B,Collagen receptor,Platelet membrane glycoprotein Ia,VLA-2 subunit alpha |
| Background | Protein ITGA2 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Integrin subunit alpha 2 (ITGA2) is part of the integrin family, a group of heterodimeric transmembrane receptors composed of alpha and beta subunits. These receptors are critical for cell-ECM (extracellular matrix) interactions and cell-cell adhesion, with a wide variety of biological processes such as cell migration, proliferation, differentiation, and signal transduction. ITGA2 forms a dimer with integrin beta 1 (ITGB1), giving rise to the α2β1 integrin, also known as the collagen receptor. This receptor specifically binds to collagen and laminin in the ECM, playing a crucial role in mediating cellular adhesion to collagen fibers in tissues. The ITGA2 gene, located on chromosome 5q11.2, encodes the alpha 2 integrin subunit. ITGA2 is expressed in various cell types, including epithelial cells, platelets, fibroblasts, and immune cells. Its activity is essential in processes such as wound healing, angiogenesis, hemostasis, and the maintenance of tissue integrity. Additionally, α2β1 integrin has significant involvement in tumor biology, where it modulates cancer cell invasion and metastasis by interacting with the ECM.
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