Human Integrin Alpha 2 (ITGa2) Protein

Este producto es parte de ITGA2 - integrin subunit alpha 2
Human Integrin Alpha 2 (ITGa2) Protein

Pida mas información

935106861

info@markelab.com

Precio

195€ (10 µg)

Protein ITGA2

proveedor

Abbexa

reference

abx168039

Tested Applications

WB, SDS-PAGE

reactivity

status

RUO

clonality

Descripción

Integrin Alpha 2 Protein is a recombinant Human protein expressed in E. coli.


Background

Integrin subunit alpha 2 (ITGA2) is part of the integrin family, a group of heterodimeric transmembrane receptors composed of alpha and beta subunits. These receptors are critical for cell-ECM (extracellular matrix) interactions and cell-cell adhesion, with a wide variety of biological processes such as cell migration, proliferation, differentiation, and signal transduction. ITGA2 forms a dimer with integrin beta 1 (ITGB1), giving rise to the α2β1 integrin, also known as the collagen receptor. This receptor specifically binds to collagen and laminin in the ECM, playing a crucial role in mediating cellular adhesion to collagen fibers in tissues. The ITGA2 gene, located on chromosome 5q11.2, encodes the alpha 2 integrin subunit. ITGA2 is expressed in various cell types, including epithelial cells, platelets, fibroblasts, and immune cells. Its activity is essential in processes such as wound healing, angiogenesis, hemostasis, and the maintenance of tissue integrity. Additionally, α2β1 integrin has significant involvement in tumor biology, where it modulates cancer cell invasion and metastasis by interacting with the ECM.

Características del producto

category

Proteins and Peptides


origin

Human


host

E. coli


immunogen target

Integrin Alpha 2 (ITGa2)


host

E. coli


conjugation

Unconjugated


form

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.


tested applications

WB, SDS-PAGE


size 1

10 µg


size 2

50 µg


size 3

100 µg


size 4

200 µg


size 5

500 µg


observerd MW

Molecular Weight: Calculated MW: 27.9 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Glu74-Val277 Tag: N-terminal His tag


expression

Recombinant


purity

> 95%


buffer

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300.


storage

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.


or code

ITGA2


dry ice

No


availability

Shipped within 5-12 working days.


alias

BR,GPIa,CD49B,HPA-5,VLA-2,VLAA2,CD49 antigen-like family member B,Collagen receptor,Platelet membrane glycoprotein Ia,VLA-2 subunit alpha


note

This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use.


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