Human Integrin Alpha 1 (ITGa1) Protein

Product specifications

Proteins and Peptides

Integrin Alpha 1 (ITGa1)

E. coli

Human

Unconjugated

Molecular Weight: Calculated MW: 33.4 kDa  Observed MW (SDS-PAGE): 32 kDa
Concentration: Prior to lyophilization: 200 µg/ml
Sequence Fragment: Gly125-Ala366
Tag: N-terminal His tag

Recombinant

> 95%

10 µg

50 µg

100 µg

200 µg

500 µg

Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex.

WB, SDS-PAGE

Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl.

Shipped within 5-7 working days.

Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles.

No

VLA-1,VLA1,CD49a,CD49 antigen-like family member A,Laminin and collagen receptor

Protein ITGA1

RUO

This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Integrin subunit alpha 1 (ITGA1) is a member of the integrin family, a group of transmembrane receptors involved in cell-extracellular matrix (ECM) adhesion and cell-cell interactions. Integrins are heterodimeric molecules composed of an alpha and beta subunit that combine to form functional receptors. These receptors are critical for mediating cell adhesion, migration, proliferation, and signal transduction across the plasma membrane. ITGA1, specifically, pairs with integrin beta 1 (ITGB1) to form the α1β1 integrin, which primarily serves as a receptor for collagen and laminin in the extracellular matrix. The ITGA1 gene, located on chromosome 5q11.2, encodes the alpha 1 subunit, which is involved in binding to collagen types I and IV. This binding plays a significant role in the regulation of cellular responses such as matrix remodeling, wound healing, inflammation, and cell differentiation. ITGA1 expression is found across various tissues, including the kidney, liver, smooth muscle cells, fibroblasts, and immune cells, reflecting its diverse physiological functions. Additionally, ITGA1 has emerged as an important player in tumor biology, where it can influence cancer cell adhesion, invasion, and metastasis.

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