Human Inducible T-Cell Co Stimulator Ligand (ICOSLG) Protein
234€ (2 µg)
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935106861
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name
Human Inducible T-Cell Co Stimulator Ligand (ICOSLG) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx680053
tested applications
SDS-PAGE
Description
Human Inducible T-Cell Co Stimulator Ligand (ICOSLG) Protein is a recombinant protein produced in Sf9, Baculovirus cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Inducible T-Cell Co Stimulator Ligand (ICOSLG) |
| Host | Insect |
| Origin | Human |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 2 µg |
| Size 2 | 10 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| Alias | ICOS ligand, B7RP1,CD275,ICOSL,LICOS,B7RP-1,ICOS-L,IMD119,B7 homolog 2 |
| Background | Protein ICOSLG |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Inducible T-cell costimulator ligand (ICOSLG), also known as B7-H2 or CD275, is a critical immunoregulatory protein in the B7 family that provides costimulatory signals to T cells. ICOSLG serves as a ligand for ICOS (Inducible T-cell Costimulator), a receptor expressed on activated T cells. Through its interaction with ICOS, ICOSLG plays an essential role in modulating adaptive immune responses, particularly influencing T-cell differentiation, proliferation, and the formation of memory T cells. This interaction is crucial for both protective immunity and immune tolerance, enabling the immune system to respond robustly to pathogens while preventing autoimmunity. ICOSLG is primarily expressed on antigen-presenting cells (APCs), such as B cells, dendritic cells (DCs), macrophages, and certain epithelial cells in mucosal tissues. Its expression is inducible and can be upregulated during inflammation or immune activation by signals from pro-inflammatory cytokines like interferon-gamma (IFN-γ). The ICOS/ICOSLG axis is especially important for the regulation of germinal center formation in lymphoid tissues, where it facilitates B cell differentiation and antibody production. ICOSLG is also implicated in the maintenance of regulatory T cells (Tregs) and T-helper 17 (Th17) cells, thereby contributing to immune homeostasis and controlling inflammation.
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