Human Inducible T-Cell Co Stimulator Ligand (ICOSLG) Protein

Este producto es parte de ICOSLG - inducible T cell costimulator ligand
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234€ (2 µg)

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935106861
info@markelab.com
name
Human Inducible T-Cell Co Stimulator Ligand (ICOSLG) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx680053
tested applications
SDS-PAGE

Description

Human Inducible T-Cell Co Stimulator Ligand (ICOSLG) Protein is a recombinant protein produced in Sf9, Baculovirus cells.

Documents del producto

Instrucciones
Data sheet
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Product specifications

Category
Proteins and Peptides
Immunogen Target
Inducible T-Cell Co Stimulator Ligand (ICOSLG)
Host
Insect
Origin
Human
Conjugation
Unconjugated
Expression
Recombinant
Purity
> 90% (SDS-PAGE)
Size 1
2 µg
Size 2
10 µg
Size 3
1 mg
Form
Liquid 
Tested Applications
SDS-PAGE
Availability
Shipped within 5-10 working days.
Dry Ice
No
Alias
ICOS ligand, B7RP1,CD275,ICOSL,LICOS,B7RP-1,ICOS-L,IMD119,B7 homolog 2
Background
Protein ICOSLG
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

Inducible T-cell costimulator ligand (ICOSLG), also known as B7-H2 or CD275, is a critical immunoregulatory protein in the B7 family that provides costimulatory signals to T cells. ICOSLG serves as a ligand for ICOS (Inducible T-cell Costimulator), a receptor expressed on activated T cells. Through its interaction with ICOS, ICOSLG plays an essential role in modulating adaptive immune responses, particularly influencing T-cell differentiation, proliferation, and the formation of memory T cells. This interaction is crucial for both protective immunity and immune tolerance, enabling the immune system to respond robustly to pathogens while preventing autoimmunity. ICOSLG is primarily expressed on antigen-presenting cells (APCs), such as B cells, dendritic cells (DCs), macrophages, and certain epithelial cells in mucosal tissues. Its expression is inducible and can be upregulated during inflammation or immune activation by signals from pro-inflammatory cytokines like interferon-gamma (IFN-γ). The ICOS/ICOSLG axis is especially important for the regulation of germinal center formation in lymphoid tissues, where it facilitates B cell differentiation and antibody production. ICOSLG is also implicated in the maintenance of regulatory T cells (Tregs) and T-helper 17 (Th17) cells, thereby contributing to immune homeostasis and controlling inflammation.

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