Human Immunoglobulin Superfamily Member 8 (IGSF8) Protein
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Description
Human PGRL Protein is a recombinant protein from Human produced in HEK293 Cells. A DNA sequence encoding the human IGSF8 (Q969P0-1) (Met1-Thr579) was expressed with a polyhistidine tag at the C-terminus.
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Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | PGRL |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: 60 kDa Sequence Fragment: Met1-Thr579 Tag: C-terminal His tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 95% (SDS-PAGE) |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Form | |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile PBS, pH 7.4. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q969P0-1 |
| Alias | EWI2,PGRL,CD316,EWI-2,KCT-4,CD81P3,LIR-D1,Prostaglandin regulatory-like protein,CD81 partner 3,Glu-Trp-Ile EWI motif-containing protein 2 |
| Background | Protein IGSF8 |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
IGSF8, also known as ECD8 or CD316, is expressed in a wide range of tissues, including immune cells, neuronal cells, and epithelial cells. It contains Ig-like domains and functions as a co-receptor involved in cell adhesion, cell signaling, and immune modulation. IGSF8 interacts with integrins and tetraspanins, playing a role in immune cell activation, antigen presentation, and synaptic organization. In the immune system, it facilitates interactions between antigen-presenting cells and T cells. Dysregulation of IGSF8 is linked to neurodegenerative diseases, such as Alzheimer’s disease, and its altered expression is observed in certain cancers, where it influences tumor-immune interactions and metastasis.
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