Human Hydroxy-Carboxylic Acid Receptor 3 / GPR109B (HCAR3) CLIA Kit
845€ (96 tests)
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935106861
info@markelab.com
name
Human Hydroxy-Carboxylic Acid Receptor 3 / GPR109B (HCAR3) CLIA Kit
category
CLIA Kits
provider
Abbexa
reference
abx495277
tested applications
CLIA
Description
Human G Protein Coupled Receptor 109B (GPR109B) Chemiluminescent Immunoassay (CLIA) Kit is a Sandwich Chemiluminescent Immunoassay (CLIA) Kit for use with Tissue homogenates, cell lysates and other biological fluids.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | CLIA Kits |
| Immunogen Target | Hydroxy-Carboxylic Acid Receptor 3 / GPR109B (HCAR3) |
| Reactivity | Human |
| Detection Method | Chemiluminescent |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Sensitivity | < 0.061 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Size 2 | 5 × 96 tests |
| Size 3 | 10 × 96 tests |
| Form | Lyophilized |
| Tested Applications | CLIA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-20 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| Alias | HCAR3,NIACR2,Low affinity nicotinic acid receptor,Nic2,G protein-coupled receptor 109B,GPR109B,HCA3,HM74, PUMAG,Puma-g |
| Background | CLIA Kits HCAR3 |
| Status | RUO |
| Note | The validity for this kit is at least 6 months. Up to 12 months validity can be provided on request. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
HCAR3, also known as GPR109B, is a G protein-coupled receptor closely related to HCAR2 and activated by nicotinic acid and specific long-chain fatty acid derivatives. It is primarily expressed in adipose tissue, immune cells, and skin, where it regulates lipid metabolism, inflammation, and immune responses. Similar to HCAR2, HCAR3 activation inhibits cAMP production through Gi/o proteins, leading to the suppression of lipolysis and decreased free fatty acid release. HCAR3 has been linked to lipid and energy homeostasis, particularly in regulating triglyceride levels and promoting energy storage. In immune cells, HCAR3 signaling mediates anti-inflammatory effects, contributing to the resolution of inflammation and tissue repair. While its physiological roles are less characterized compared to HCAR2, HCAR3 is emerging as a potential target for metabolic and inflammatory diseases. HCAR3 expression in the skin has also been associated with niacin-induced flushing, a side effect relevant to lipid-lowering therapies. Its involvement in lipid regulation and immune modulation makes HCAR3 a candidate for therapeutic interventions targeting metabolic and inflammatory disorders.
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