Human Homeobox protein aristaless-like 4 (ALX4) ELISA Kit
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Description
Human Homeobox protein aristaless-like 4 (ALX4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Homeobox protein aristaless-like 4 (ALX4) concentrations in tissue homogenates, cell lysates and other biological fluids.
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Product specifications
| Category | ELISA Kits |
| Immunogen Target | Homeobox protein aristaless-like 4 (ALX4) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. The validity for this kit is 6 months. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9H161 |
| Alias | CRS5,FND2 |
| Background | Elisa kits for ALX4 |
| Status | RUO |
| Note | Validity: The validity for this kit is 6 months. This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. |
Descripción
ALX4 is a homeobox transcription factor critical for skeletal development, limb formation, and hair follicle regulation. ALX4 is highly expressed in mesenchymal progenitor cells during embryonic development, where it regulates the formation of cranial bones, limbs, and other skeletal structures. Mutations in ALX4 are associated with parietal foramina, a congenital condition characterized by defects in skull ossification, as well as alopecia and hair pattern abnormalities. ALX4 functions by coordinating signaling pathways such as Wnt and BMP, which control mesenchymal differentiation, osteoblast activity, and hair follicle cycling. Loss of ALX4 function can lead to delayed skull closure, limb malformations, and impaired bone mineralization. ALX4 is also implicated in tumor suppression, as its downregulation has been observed in cancers where mesenchymal regulation is disrupted. Its role in skeletal and hair follicle development underscores its importance as a key regulator of mesenchymal differentiation and morphogenesis.
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This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2) ; an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del (11) (p11p12), causes Potocki-Shaffer syndrome (PSS) ; a syndrome characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart. [provided by RefSeq].
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