Human Homeobox protein aristaless-like 4 (ALX4) ELISA Kit
715€ (96 tests)
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Name
Human Homeobox protein aristaless-like 4 (ALX4) ELISA Kit
Category
ELISA Kits
Provider
Abbexa
Reference
abx501607
Tested Applications
ELISA
Description
Human Homeobox protein aristaless-like 4 (ALX4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Homeobox protein aristaless-like 4 (ALX4) concentrations in tissue homogenates, cell lysates and other biological fluids.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | ELISA Kits |
| Immunogen Target | Homeobox protein aristaless-like 4 (ALX4) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Test Range | 0.156 ng/ml - 10 ng/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-15 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | Q9H161 |
| Alias | CRS5,FND2 |
| Background | Elisa Kits for: ALX4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Background
ALX4 is a homeobox transcription factor critical for skeletal development, limb formation, and hair follicle regulation. ALX4 is highly expressed in mesenchymal progenitor cells during embryonic development, where it regulates the formation of cranial bones, limbs, and other skeletal structures. Mutations in ALX4 are associated with parietal foramina, a congenital condition characterized by defects in skull ossification, as well as alopecia and hair pattern abnormalities. ALX4 functions by coordinating signaling pathways such as Wnt and BMP, which control mesenchymal differentiation, osteoblast activity, and hair follicle cycling. Loss of ALX4 function can lead to delayed skull closure, limb malformations, and impaired bone mineralization. ALX4 is also implicated in tumor suppression, as its downregulation has been observed in cancers where mesenchymal regulation is disrupted. Its role in skeletal and hair follicle development underscores its importance as a key regulator of mesenchymal differentiation and morphogenesis.
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