Human Histamine N-Methyltransferase (HNMT) Protein
1079€ (50 µg)
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935106861
info@markelab.com
name
Human Histamine N-Methyltransferase (HNMT) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx693080
tested applications
SDS-PAGE
Description
Human HNMT Protein is a recombinant protein from Human produced in E. coli. A DNA sequence encoding the human HNMT (AAH20677.1) (Met 1-Ala 292) was fused with the GST tag at the N-terminus.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | HNMT |
| Host | E. coli |
| Origin | Human |
| Observed MW | Molecular Weight: 60.5 kDa Sequence Fragment: Met1-Ala292 Tag: N-terminal GST tag Validity: The validity for this protein is 12 months. |
| Expression | Recombinant |
| Purity | > 85% (SDS-PAGE) |
| Size 1 | 50 µg |
| Tested Applications | SDS-PAGE |
| Buffer | Lyophilized from sterile 20mM Tris, 0.15M NaCl, pH 7.5. |
| Availability | Shipped within 5-15 working days. |
| Storage | Aliquot and store at -20°C or -80°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | AAH20677.1 |
| Background | Protein HNMT |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
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In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene.
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