Human High Affinity Immunoglobulin Gamma Fc Receptor I / CD64 (FCGR1A) Protein

Este producto es parte de FCGR1A - Fc gamma receptor Ia
Product Graph
416€ (20 µg)

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935106861
info@markelab.com
name
Human High Affinity Immunoglobulin Gamma Fc Receptor I / CD64 (FCGR1A) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx694204
tested applications
SDS-PAGE

Description

Human High Affinity Immunoglobulin Gamma Fc Receptor I / CD64 (FCGR1A) Protein is a recombinant Human protein expressed in HEK293 cells.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Proteins and Peptides
Immunogen Target
High Affinity Immunoglobulin Gamma Fc Receptor I / CD64 (FCGR1A)
Host
HEK293 cells
Origin
Human
Observed MW
Molecular Weight: Calculated MW: 31.57 kDa  Observed MW (SDS-PAGE): 35 kDa
Sequence Fragment: Met1-Pro288
Tag: C-terminal His tag
Expression
Recombinant
Purity
>95% (SDS-PAGE)
Size 1
20 µg
Size 2
100 µg
Form
Lyophilized Reconstitute in sterile H2O. Do not vortex.
Tested Applications
SDS-PAGE
Buffer
Prior to lyophilization: PBS, pH 7.4, containing 5% - 8% Trehalose, Mannitol and 0.01% Tween-80.
Availability
Shipped within 5-15 working days.
Storage
Store lyophilized between -20 °C and -80 °C.
Dry Ice
No
UniProt ID
P12314
Gene ID
2209
OMIM
146760
Alias
CD64,FCG1,FCRI,CD64A,FCGR1,IGFR1,FcgammaRI,High affinity immunoglobulin gamma Fc receptor I,IgG Fc receptor I,Fc-gamma RIA
Background
Protein FCGR1A
Status
RUO
Note
This product is for research use only.   Not for human consumption, cosmetic, therapeutic or diagnostic use.

Descripción

FCGR1A (Fc gamma receptor Ia), also known as CD64, is a high-affinity receptor for the Fc region of immunoglobulin G (IgG) antibodies. It plays a crucial role in immune responses by binding to the Fc portion of IgG, mediating various immune functions such as phagocytosis, antibody-dependent cellular cytotoxicity (ADCC), and immune complex clearance. FCGR1A is predominantly expressed on monocytes, macrophages, and dendritic cells, as well as on neutrophils during inflammatory responses. The interaction between FCGR1A and IgG antibodies bridges innate and adaptive immunity, facilitating the elimination of pathogens and other foreign particles. It is also critical in the regulation of immune responses by modulating inflammatory signals. FCGR1A is involved in the recognition of opsonized particles, initiating signaling cascades that result in cytokine production, phagocytosis, and the clearance of immune complexes.

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