Human High Affinity Immunoglobulin Gamma Fc Receptor I / CD64 (FCGR1A) Protein
416€ (20 µg)
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name
Human High Affinity Immunoglobulin Gamma Fc Receptor I / CD64 (FCGR1A) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx694204
tested applications
SDS-PAGE
Description
Human High Affinity Immunoglobulin Gamma Fc Receptor I / CD64 (FCGR1A) Protein is a recombinant Human protein expressed in HEK293 cells.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | High Affinity Immunoglobulin Gamma Fc Receptor I / CD64 (FCGR1A) |
| Host | HEK293 cells |
| Origin | Human |
| Observed MW | Molecular Weight: Calculated MW: 31.57 kDa Observed MW (SDS-PAGE): 35 kDa Sequence Fragment: Met1-Pro288 Tag: C-terminal His tag |
| Expression | Recombinant |
| Purity | >95% (SDS-PAGE) |
| Size 1 | 20 µg |
| Size 2 | 100 µg |
| Form | Lyophilized Reconstitute in sterile H2O. Do not vortex. |
| Tested Applications | SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 5% - 8% Trehalose, Mannitol and 0.01% Tween-80. |
| Availability | Shipped within 5-15 working days. |
| Storage | Store lyophilized between -20 °C and -80 °C. |
| Dry Ice | No |
| UniProt ID | P12314 |
| Gene ID | 2209 |
| OMIM | 146760 |
| Alias | CD64,FCG1,FCRI,CD64A,FCGR1,IGFR1,FcgammaRI,High affinity immunoglobulin gamma Fc receptor I,IgG Fc receptor I,Fc-gamma RIA |
| Background | Protein FCGR1A |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
FCGR1A (Fc gamma receptor Ia), also known as CD64, is a high-affinity receptor for the Fc region of immunoglobulin G (IgG) antibodies. It plays a crucial role in immune responses by binding to the Fc portion of IgG, mediating various immune functions such as phagocytosis, antibody-dependent cellular cytotoxicity (ADCC), and immune complex clearance. FCGR1A is predominantly expressed on monocytes, macrophages, and dendritic cells, as well as on neutrophils during inflammatory responses. The interaction between FCGR1A and IgG antibodies bridges innate and adaptive immunity, facilitating the elimination of pathogens and other foreign particles. It is also critical in the regulation of immune responses by modulating inflammatory signals. FCGR1A is involved in the recognition of opsonized particles, initiating signaling cascades that result in cytokine production, phagocytosis, and the clearance of immune complexes.
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