Human Hepatocyte Nuclear Factor 4 Alpha (HNF4a) Protein
247€ (10 µg)
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935106861
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name
Human Hepatocyte Nuclear Factor 4 Alpha (HNF4a) Protein
category
Proteins and Peptides
provider
Abbexa
reference
abx067075
tested applications
WB, SDS-PAGE
Description
Recombinant Hepatocyte Nuclear Factor 4 Alpha (HNF4a) is a recombinant Human protein produced in a Prokaryotic expression system (E. coli).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Proteins and Peptides |
| Immunogen Target | Hepatocyte Nuclear Factor 4 Alpha (HNF4a) |
| Host | E. coli |
| Origin | Human |
| Conjugation | Unconjugated |
| Observed MW | Molecular Weight: Calculated MW: 26.5 kDa Concentration: Prior to lyophilization: 200 µg/ml Sequence Fragment: Gln131-Ser330 Tag: N-terminal His tag |
| Expression | Recombinant |
| Purity | > 90% |
| Size 1 | 10 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 500 µg |
| Form | Lyophilized To keep the original salt concentration, we recommend reconstituting to the original concentration prior to lyophilization (see Concentration) in ddH2O. If a lower concentration is required, dilute in PBS, pH 7.4. If a higher concentration is required, the product can be reconstituted directly in PBS, pH 7.4, though please note that this will change the overall salt concentration. The stock concentration should be between 0.1-1.0 mg/ml. Do not vortex. |
| Tested Applications | WB, SDS-PAGE |
| Buffer | Prior to lyophilization: PBS, pH 7.4, containing 0.01% Sarcosyl, 1 mM DTT, 5% Trehalose and Proclin-300. |
| Availability | Shipped within 5-7 working days. |
| Storage | Store at 2-8 °C for up to one month. Store at -80 °C for up to one year. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P41235 |
| Alias | TCF,HNF4,MODY,FRTS4,MODY1,NR2A1,TCF14,HNF4a7,HNF4a8,HNF4a9,NR2A21,TCF-14,HNF4alpha,Transcription factor HNF-4,Nuclear receptor subfamily 2 group A member 1 |
| Background | Protein HNF4A |
| Status | RUO |
| Note | This product is for research use only. Not for human consumption, cosmetic, therapeutic or diagnostic use. |
Descripción
Hepatocyte nuclear factor 4 alpha (HNF4A) is a critical transcription factor that plays a key role in regulating liver function, metabolism, and the development of the gastrointestinal tract HNF4A is highly expressed in the liver, where it controls the expression of genes involved in hepatic glucose production, lipid metabolism, and bile acid synthesis It also regulates the development and differentiation of liver cells and contributes to maintaining liver homeostasis HNF4A is involved in controlling genes responsible for the metabolism of steroids, carbohydrates, and lipids, and it is crucial for maintaining the liver's metabolic functions Dysregulation of HNF4A has been associated with metabolic diseases, such as diabetes, non-alcoholic fatty liver disease (NAFLD), and liver cirrhosis In addition, mutations in the HNF4A gene can lead to maturity-onset diabetes of the young (MODY), a form of diabetes characterized by early-onset, autosomal dominant inheritance of insulin resistance
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