Human Heparin Cofactor II (SERPIND1) ELISA Kit
611€ (96 tests)
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name
Human Heparin Cofactor II (SERPIND1) ELISA Kit
category
ELISA Kits
provider
Abbexa
reference
abx570183
tested applications
ELISA
Description
Human Heparin Cofactor II (SERPIND1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Heparin cofactor 2 concentrations in serum, tissue homogenates, cell lysates and other biological fluids. The analyte concentration is higher in plasma than in other sample types, therefore for plasma samples, it is recommended to use the
Documents del producto
Product specifications
| Category | ELISA Kits |
| Immunogen Target | Heparin Cofactor II (SERPIND1) |
| Reactivity | Human |
| Detection Method | Colorimetric |
| Assay Data | Quantitative |
| Assay Type | Sandwich |
| Test Range | 31.2 pg/ml - 2000 pg/ml |
| Sensitivity | < 16 pg/ml |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 96 tests |
| Form | Standard Form: Lyophilized |
| Tested Applications | ELISA |
| Sample Type | Serum, plasma, tissue homogenates, cell lysates and other biological fluids. |
| Availability | Shipped within 5-12 working days. |
| Storage | Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual. |
| Dry Ice | No |
| UniProt ID | P05546 |
| Alias | HC2,LS2,HCF2,HCII,HLS2,THPH10,D22S673,Heparin cofactor 2,Heparin cofactor II,Protease inhibitor leuserpin-2,Serpin D1 |
| Background | Elisa Kits for: SERPIND1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein. The stability of the kit is determined by the rate of activity loss. The loss rate is less than 5% within the expiration date under appropriate storage conditions. To minimize performance fluctuations, operation procedures and lab conditions should be strictly controlled. It is also strongly suggested that the whole assay is performed by the same user throughout. |
Descripción
SERPIND1 encodes Heparin Cofactor II (HCII), a serine protease inhibitor (serpin) that plays a critical role in the regulation of coagulation. It shares functional similarities with antithrombin (SERPINC1), particularly in inhibiting thrombin, a key enzyme in the coagulation cascade. However, HCII exhibits a more specialized function as its activity is highly dependent on heparin-like glycosaminoglycans (GAGs), particularly dermatan sulfate, and to a lesser extent, heparin. HCII's involvement in thrombin inhibition and its activation through GAGs have made it an essential component in controlling clot formation and preventing thrombosis, particularly in vascular tissue. HCII deficiency has been linked to a predisposition for thromboembolic disorders and cardiovascular diseases.
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