Human Heparin Cofactor II (SERPIND1) ELISA Kit
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935106861
info@markelab.com
Precio
611€ (96 tests)
Elisa kits for SERPIND1
proveedor
Abbexareference
abx570183Tested Applications
ELISAreactivity
Humanstatus
RUOclonality
Descripción
Human Heparin Cofactor II (SERPIND1) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human Heparin cofactor 2 concentrations in serum, tissue homogenates, cell lysates and other biological fluids. The analyte concentration is higher in plasma than in other sample types, therefore for plasma samples, it is recommended to use the
Background
SERPIND1 encodes Heparin Cofactor II (HCII), a serine protease inhibitor (serpin) that plays a critical role in the regulation of coagulation. It shares functional similarities with antithrombin (SERPINC1), particularly in inhibiting thrombin, a key enzyme in the coagulation cascade. However, HCII exhibits a more specialized function as its activity is highly dependent on heparin-like glycosaminoglycans (GAGs), particularly dermatan sulfate, and to a lesser extent, heparin. HCII's involvement in thrombin inhibition and its activation through GAGs have made it an essential component in controlling clot formation and preventing thrombosis, particularly in vascular tissue. HCII deficiency has been linked to a predisposition for thromboembolic disorders and cardiovascular diseases.
Características del producto
category
ELISA Kits
immunogen target
Heparin Cofactor II (SERPIND1)
reactivity
Human
test range
31.2 pg/ml - 2000 pg/ml
sensitivity
< 16 pg/ml
assay type
Sandwich
assay data
Quantitative
form
Lyophilized
detection method
Colorimetric
sample type
Serum, plasma, tissue homogenates, cell lysates and other biological fluids.
size 1
96 tests
alias
HC2,LS2,HCF2,HCII,HLS2,THPH10,D22S673,Heparin cofactor 2,Heparin cofactor II,Protease inhibitor leuserpin-2,Serpin D1
storage
Shipped at 4 °C. Upon receipt, store the kit according to the storage instruction in the kit's manual.
or code
SERPIND1
dry ice
No
uniprot id
note
This product is for research use only. The range and sensitivity is subject to change. Please contact us for the latest product information. For accurate results, sample concentrations must be diluted to mid-range of the kit. If you require a specific range, please contact us in advance or write your request in your order comments. Please note that our ELISA and CLIA kits are optimised for detection of native samples, rather than recombinant proteins. We are unable to guarantee detection of recombinant proteins, as they may have different sequences or tertiary structures to the native protein.
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